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Updated: Mar 11, 2026

In Vitro and In Vivo Detection of Mitophagy in Human Cells, C. Elegans, and Mice
Published on: November 22, 2017
The role of autophagy in mycotoxin-induced toxicity: A review
Yuke Xu1, Mengjie Liu2, Jiashe Chen1
1Department of Pathology, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai 200443, China.
Abstract:
Mycotoxins are widespread toxic secondary metabolites produced by fungi, posing substantial health risks to humans and animals. Recent studies have highlighted the crucial role of autophagy in mediating mycotoxin-induced toxicity. As a highly conserved intracellular degradation pathway, autophagy maintains cellular homeostasis by selectively removing damaged organelles and misfolded protein aggregates. However, its function in the context of mycotoxin exposure is dualistic: it can act either as a protective mechanism or contribute to detrimental cellular outcomes. This review focuses on recent advances in understanding the role of autophagy in mycotoxin-induced toxicity and discusses potential intervention strategies by targeting the autophagy pathway.
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