Related Experiment Video
Updated: Mar 11, 2026

Study of Experimental Organ Donation Models for Lung Transplantation
Published on: March 15, 2024
Life After Death: Ethical Considerations of CPR in Brain-Dead Pediatric Organ Donors
Jenny Kingsley1,2, Miriam Piven Cotler3,4, Brenda Barnum2,5
1University of Southern California Keck School of Medicine, Los Angeles, California.
Insights
Organ-preserving cardiopulmonary resuscitation (OP-CPR) for pediatric organ donation presents ethical challenges. Perspectives vary on its justification, balancing organ availability with donor dignity and communication needs.
Area of Science:
- Medical Ethics
- Pediatric Critical Care
- Organ Donation and Transplantation
Background:
- Organ-preserving cardiopulmonary resuscitation (OP-CPR) is used in pediatric organ donation after neurological determination of death.
- Ethical tensions exist between maximizing organ viability and respecting the deceased donor's bodily integrity.
Purpose of the Study:
- To explore the ethical complexities of OP-CPR in pediatric organ donation.
- To present diverse perspectives on the justification and implementation of OP-CPR.
Main Methods:
- Case study analysis of a pediatric patient (JJ).
- Presentation of three distinct viewpoints: an organ procurement organization ethicist, pediatric critical care physicians/bioethicists, and pediatric intensive care unit nurses.
Main Results:
- An OPO ethicist supports OP-CPR for justice and organ availability.
- Physicians/bioethicists question OP-CPR's ethical justification due to low success rates and potential harm to donor dignity.
- Nurses report communication challenges, moral distress, and policy issues with OP-CPR.
Conclusions:
- Clear guidelines and improved collaboration between PICU teams and OPOs are necessary for OP-CPR.
- Ethical frameworks must address conscientious objection and commitment in OP-CPR practices.
- Further dialogue is needed to navigate the ethical landscape of pediatric organ donation.
Abstract:
The ethical considerations surrounding organ-preserving cardiopulmonary resuscitation (OP-CPR) in pediatric patients with brain death highlight tensions between preserving organ viability and respecting bodily integrity. This article explores these complexities through the case of JJ, a 12-year-old patient declared dead by neurological criteria, whose parents authorized organ donation. When JJ experienced cardiovascular collapse before organ procurement, the organ procurement organization's off-site director instructed hospital staff to perform OP-CPR, prompting ethical concerns from the pediatric intensive care unit (PICU) team. This Ethics Rounds article presents 3 perspectives on OP-CPR: (1) An ethicist working for an organ procurement organization asserts that OP-CPR aligns with the family's intent and the principle of justice by increasing organ availability; (2) 2 pediatric intensive care attendings and bioethicists argue OP-CPR may not be ethically justified due to the low likelihood of achieving the primary goal, potential harm to the donor's dignity and personhood, and concerns about poor communication and lack of explicit permission; and (3) 3 nurses reveal challenges related to communication, moral distress, and institutional policies that pertain to the practice of OP-CPR. The article underscores the need for clear guidelines, improved collaboration between PICU teams and organ procurement organizations, and ethical frameworks that address both conscientious objection and conscientious commitment in the context of OP-CPR.
Related Concept Videos
Kidney Transplant I: Introduction
Cardiopulmonary Resuscitation I: Adult
Cardiopulmonary Resuscitation IV: Pharmacological Management

