Related Experiment Video

Updated: Jun 18, 2026

Author Spotlight: Three-Dimensional Cephalometric Landmark Annotation Demonstration on Human Cone Beam Computed Tomography Scans
10:23

Author Spotlight: Three-Dimensional Cephalometric Landmark Annotation Demonstration on Human Cone Beam Computed Tomography Scans

Published on: September 8, 2023

3.8K

Tinea Capitis and Down Syndrome: A Multi-Center Retrospective Cohort Study

Khaled Seetan1, Almu'atasim Khamees1,2, Raghad Yousef Yassin3

  • 1Department of Clinical Sciences, Faculty of Medicine, Yarmouk University, Irbid, Jordan.

Pediatric Dermatology
|March 9, 2026
PubMed

Insights

Children with Down syndrome (DS) experience more severe tinea capitis infections, including increased inflammation and unique fungal profiles. These children also show poorer treatment response and higher recurrence rates for this common scalp infection.

Area of Science:

  • Dermatology
  • Pediatrics
  • Infectious Diseases

Background:

  • Tinea capitis is a common fungal infection in children.
  • Limited data exists on tinea capitis in children with Down syndrome (DS).
  • This study compares tinea capitis presentation and treatment in children with and without DS.

Purpose of the Study:

  • To describe and compare clinical presentation, mycological findings, and treatment response of tinea capitis in children with and without Down syndrome (DS).

Main Methods:

  • Retrospective cohort study of 1320 pediatric tinea capitis cases (112 with DS) across three Jordanian dermatology centers (2015-2024).
  • Multivariate regression and time-to-event analyses compared clinical symptoms, causative dermatophytes, and treatment outcomes between groups.
  • Data included demographics, clinical signs, fungal species, treatment regimens, and resolution times.

Main Results:

  • Children with DS had a higher incidence of inflammatory tinea capitis, particularly kerion (42.9% vs. 18.5%).
  • Trichophyton violaceum was more prevalent in children with DS (58.9% vs. 42.1%), while Microsporum canis was less frequent (13.4% vs. 25.6%).
  • Clinical cure rates at 8 weeks were lower in children with DS (61.6% vs. 78.9%), with a longer median resolution time (10.4 vs. 7.3 weeks). DS was an independent predictor of treatment failure and recurrence.

Conclusions:

  • Tinea capitis in children with Down syndrome presents with increased inflammation and distinct mycological characteristics.
  • Children with DS exhibit poorer treatment response and higher recurrence rates for tinea capitis.
  • Findings aid healthcare providers in optimizing management of tinea capitis in pediatric patients with DS.
Abstract

Keywords:
dermatophytedown syndromepediatric dermatologytinea capitistreatment outcomestrisomy 21

More Related Videos

A Pediatric Concussion Model in Mice: Closed Head Injury with Long-Term Disorders (CHILD)07:01

A Pediatric Concussion Model in Mice: Closed Head Injury with Long-Term Disorders (CHILD)

Published on: February 7, 2025

946
Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model08:03

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model

Published on: November 4, 2025

358

Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Cryptococcal Meningitis01:27

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
Alzheimer Disease l: Introduction01:29

Alzheimer Disease l: Introduction

Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...