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Disulfiram attenuates immobilization-induced knee joint contracture by suppressing Caspase-1/GSDMD-mediated

Qian Lu1, Xiuli Kan1, Quanbing Zhang1

  • 1Department of Rehabilitation Medicine, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, Anhui, China.

Scientific Reports
|March 10, 2026
PubMed
Abstract

No abstract available in PubMed .

Keywords:
Caspase-1/GSDMDDisulfiramarthrogenic contracturefibrosispyroptosis

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Skeletal muscle relaxants are widely used for muscle paralysis and relieving pain following any muscle injury or stiffness. However, depending on the drug type, they can have adverse effects that range from mild to severe. Usually, nondepolarizing neuromuscular blockers have minimal side effects. For example, drugs like d-tubocurarine, cisatracurium, and rocuronium cause hypotension, whereas drugs like baclofen, when stopped abruptly, can lead to the recurrence of spastic conditions.
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