Related Experiment Video

Updated: Mar 11, 2026

Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation
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Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation

Published on: February 28, 2019

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TGEV activates RIG-I/IFN-β/STAT1 axis to promote NLRC5-mediated SLA-I upregulation.

Wenqian Wang1,2,3, Mengyao Ma1,4,2,3, Haojie Bai1,2,3

  • 1College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, 450046, China.

Veterinary Research
|March 10, 2026
PubMed
Summary

Porcine transmissible gastroenteritis virus (TGEV) infection upregulates swine leukocyte antigen class I (SLA-I) via the RIG-I/IFN-β/STAT1 pathway. This immune response, mediated by NLRC5, inhibits TGEV proliferation, offering insights into host defense against enteric coronaviruses.

Keywords:
NLRC5Porcine transmissible gastroenteritis virusSLA-Iviral proliferation

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