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Teratogenicity

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...

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Instrumentation of Near-term Fetal Sheep for Multivariate Chronic Non-anesthetized Recordings

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Does the Reproductive Technique Affect Neonatal Health Parameters in Foals?

Maria Augusta Alonso¹, Giovana Rodrigues Dos Santos¹, Juliana Schleich Fonte^1,2

¹Animal Reproduction Department, College of Veterinary Medicine and Animal Science - University of São Paulo, São Paulo, São Paulo, Brazil.

Reproduction in Domestic Animals = Zuchthygiene

|March 10, 2026

Summary

Reproductive biotechnologies like artificial insemination (AI), embryo transfer (ET), and intracytoplasmic sperm injection (ICSI) do not impact foal neonatal behavior. Factors such as farm management and breed are more influential on foal outcomes.

Keywords:

ICSI biotechnology embryo neonatal parameters parturiations

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Area of Science:

Veterinary Science
Reproductive Biology
Equine Health

Background:

Neonatal behavior is crucial for foal survival and development.
Advanced reproductive biotechnologies are increasingly used in horse breeding.
Understanding the impact of these technologies on neonatal parameters is essential.

Purpose of the Study:

To investigate the influence of different reproductive techniques on neonatal behavior in foals.
To compare foals conceived via artificial insemination (AI), conventional embryo transfer (ET), and intracytoplasmic sperm injection (ICSI).
To identify factors affecting neonatal health parameters in foals.

Main Methods:

Retrospective analysis of 102 foalings from two commercial breeding farms.
Data collection included birth weight, time to sternal recumbency, stand, nurse, and meconium elimination.
Mixed statistical models were used to assess the influence of reproductive technique, breed, sex, and farm.

Main Results:

No significant differences in neonatal parameters were found among foals conceived by AI, ET, or ICSI.
Significant differences were observed between farms for time to sternal recumbency and nursing.
Breed influenced birth height and time to meconium elimination.

Conclusions:

Reproductive biotechnologies, including ICSI, do not adversely affect neonatal health parameters in foals.
Environmental (farm management) and genetic (breed) factors play a significant role in neonatal outcomes.
These findings support the safe use of advanced reproductive techniques in equine breeding.