Effect of occupation on assisted reproduction outcomes in an oocyte donor model

Previous studies have linked workplace conditions, including chemical and physical exposures, and reproductive health outcomes in women. Our study included 603 oocyte donors who underwent 967 controlled ovarian hyperstimulation (COH) cycles for planned oocyte vitrification between 2008 and 2020. Cohorts of oocytes were then thawed and fertilized with resultant embryos utilized by intended parents. In our cohort of young, healthy oocyte donors, those employed in "healthcare practitioners and technical" occupations and in "office and administrative support" roles had lower ovarian reserve testing by antral follicle count and fewer mature oocytes retrieved COH when compared to the reference group. In vitro fertilization and embryo transfer outcomes, including live birth, for oocyte recipients were not statistically different between occupation groups when compared to the reference group. Future research is needed to clarify specific occupational exposures that may be driving these observed differences.