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Related Concept Videos

Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

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Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
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Functions of Thyroid Hormones01:18

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The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
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The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
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Skeleton and Calcium Homeostasis01:21

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Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
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Synthesis and Functions of Calcitonin00:51

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Calcitonin, a vital polypeptide hormone, regulates calcium levels within body fluids. It is released by the parafollicular cells, also known as C cells, situated in the follicular epithelium of the thyroid gland. Calcitonin responds to fluctuations in blood calcium levels and the influence of gastrointestinal hormones like gastrin and cholecystokinin.
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Hormones intricately bind to receptors on the surface or within target cells, initiating a cascade of cellular responses.
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Updated: Mar 11, 2026

Author Spotlight: Integrating Ultrasound Imaging with Biochemical Markers for Thyroid Disease Diagnosis
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ASSOCIATION PROPERTIES OF COMPLETE BLOOD COUNT FOR LEVELS OF THYROID STIMULATING HORMONE.

A Ibrahim1, A Albarhawi2, A Saadi3

  • 11College of Pharmacy, University of Mosul, Iraq.

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|March 10, 2026
PubMed
Summary
This summary is machine-generated.

Mean platelet volume (MPV) and platelet distribution width (PDW) correlate with thyroid-stimulating hormone (TSH) levels, suggesting their potential as indicators in hypothyroidism diagnosis and monitoring. Other complete blood count (CBC) parameters showed no significant association.

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Area of Science:

  • Endocrinology
  • Hematology
  • Clinical Pathology

Background:

  • Thyroid disorders, including hypothyroidism and hyperthyroidism, are common in clinical practice.
  • Assessing mean platelet volume (MPV) for thrombotic risk in hypothyroidism is valuable.
  • Complete blood count (CBC) analysis aids in discovering and monitoring thyroid dysfunction.

Purpose of the Study:

  • To investigate correlations between CBC parameters and thyroid-stimulating hormone (TSH) levels.
  • To evaluate CBC as a potential marker for cardiovascular risk and inflammation.
  • To identify cutoff values in CBC indices for suspected hypothyroidism.

Main Methods:

  • A retrospective study involving 92 patients with suspected hypothyroidism.
  • Collected data included complete blood count (CBC) and thyroid-stimulating hormone (TSH) tests.
  • Statistical analysis was performed to determine associations.

Main Results:

  • A significant positive correlation was observed between mean platelet volume (MPV) and TSH levels.
  • Significant differences in mean TSH were found based on MPV (≥10 fL vs. <10 fL) and platelet distribution width (PDW) (≤12 vs. >12).
  • A significant positive correlation existed between MPV and PDW, with notable differences in MPV across TSH level ranges.

Conclusions:

  • Mean platelet volume (MPV) and platelet distribution width (PDW) show a correlation with TSH levels.
  • Cutoff values of 10 fL for MPV and 12 fL for PDW are associated with hypothyroidism.
  • Other CBC parameters lack significant association with TSH levels.