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Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

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Anti-Inflammatory Reliever Therapy in Asthma: A Review.

Richard Beasley^1,2, Mitesh Patel³, Karen Oldfield¹

¹Medical Research Institute of New Zealand Wellington New Zealand.

Journal of the Royal Society of New Zealand

|March 10, 2026

Summary

Anti-inflammatory reliever (AIR) therapy, using inhaled corticosteroids and beta2-agonists, significantly reduces asthma exacerbations. Guidelines now recommend these inhalers over short-acting beta2-agonists for better asthma control.

Keywords:

albuterol anti‐inflammatory reliever therapy asthma formoterol inhaled corticosteroid salbutamol short‐acting beta2‐agonist

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Area of Science:

Respiratory Medicine
Pharmacology

Background:

Anti-inflammatory reliever (AIR) therapy involves 2-in-1 inhalers combining corticosteroids and beta2-agonists for asthma relief.
Current research predominantly features inhaled corticosteroid (ICS)/long-acting beta2-agonist (LABA) formoterol and ICS/short-acting beta2-agonist (SABA) albuterol combinations.

Purpose of the Study:

To review the evidence and guideline recommendations for AIR therapy in asthma management.
To highlight the shift in asthma management paradigms driven by AIR therapy.

Main Methods:

Analysis of high-quality randomized controlled trials (RCTs) evaluating AIR therapy.
Review of current New Zealand and international asthma management guidelines.

Main Results:

RCTs demonstrate a substantial reduction in severe asthma exacerbations with AIR therapy.
ICS/formoterol is recommended as the preferred reliever inhaler for adolescents and adults.
ICS/SABA reliever is now an alternative to SABA reliever therapy.

Conclusions:

AIR therapy represents a significant advancement in asthma management.
Updated guidelines recommend ICS/formoterol and ICS/SABA reliever regimens for improved asthma control and reduced exacerbations.