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Published on: April 19, 2015
Promoting Prosthesis-Soft Tissue Integration Through Micro-Nano Topographical Regulation of Tendon-Derived Stem Cell
Ying Song1,2, Yunyun Feng3, Huanyu Liu1
1Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Research Center of Denta Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, Shandong, China.
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To address the challenge of poor prosthesis-soft tissue integration in jawbone defect repair, this study proposes a dual strategy encompassing 'mechanical adaptation' and 'biological regulation'. A micro-nano hierarchical structure was constructed on the surface of Titanium-6Aluminum-4Vanadium(Ti6Al4V) implants. Wavy micro-grooves were fabricated using ultraviolet laser etching to enhance mechanical anchoring and stress dissipation, while titanium dioxide nanotube arrays were generated through anodic oxidation to regulate cellular behavior. This composite structure improved the mechanical stability of the interface and promoted tenogenic differentiation of tendon-derived stem cells, thereby achieving simultaneous mechanical integration and biological healing. This study provides a novel approach to overcoming the clinical challenges associated with prosthesis-soft tissue integration.
