Short-Term Changes in Retinal Activity With Four Myopia Control Spectacle Lenses

Area of Science:

• Ophthalmology and Optometry
• Retinal Physiology
• Myopia Control Research

Background:

• Myopia control spectacle lenses aim to slow myopia progression.
• Understanding their impact on retinal function is crucial for efficacy.
• Different lens designs create unique peripheral defocus profiles.

Purpose of the Study:

• To investigate how defocus from four myopia control spectacle lenses affects retinal function.
• To compare the electrophysiological responses induced by different lenslet designs.

Main Methods:

• Nineteen young myopic adults participated.
• Four types of myopia control lenses were tested: Aura 3, Aura 6, DIMS, and HALT.
• Retinal function was assessed using full-field electroretinography (ERG), pattern ERG, and multifocal ERG at baseline, 30 minutes, and 15 days.

Main Results:

• Aura 6 and Aura 3 lenses showed specific ERG amplitude increases (a-wave and b-wave, respectively) by day 15.
• All lenses caused short-term pattern ERG increases, with some designs maintaining higher responses.
• HALT lenses demonstrated the most sustained amplitude increases in peripheral regions and reduced implicit times.
• Aura 6 showed progressive but partially transient increases, while Aura 3 had delayed enhancements.
• DIMS lenses induced early changes that diminished by day 15.

Conclusions:

• Myopia control spectacle lenses induce distinct retinal electrophysiological responses based on their optical design.
• Lenses with widely distributed patterns (HALT, Aura 6) most consistently altered peripheral and inner retinal function.
• Optical defocus from these lenses can modulate retinal activity, potentially influencing eye growth regulation.