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Defining the Determinants of Tissue Perfusion at the Bedside in Septic Shock Patients

Michael R Pinsky1

  • 1Michael R. Pinsky, M.D.: Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.

Anesthesiology
|March 10, 2026
PubMed
Abstract

No abstract available in PubMed .

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Factors Affecting Drug Distribution: Organ Perfusion Rate01:15

Factors Affecting Drug Distribution: Organ Perfusion Rate

Drug distribution within the body is a complex process influenced by several factors, including perfusion rate, the rate at which the bloodstream transports drugs to tissue. This limitation becomes particularly significant when dealing with highly lipophilic drugs. In such cases, the rate at which the drug can move across membranes is crucial, and if the membrane is highly permeable to the drug, distribution becomes rate-limited by perfusion.
Perfusion rate-limited distribution relies on the...
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