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Updated: Mar 12, 2026

A Familial Hypercholesterolemia Human Liver Chimeric Mouse Model Using Induced Pluripotent Stem Cell-derived Hepatocytes
Published on: September 15, 2018
Extracellular vesicles related to familial hypercholesterolemia
Júnea P de P Silvino1, Cinthia E Jannes2, Rodrigo M C Pestana1
1Universidade Federal de Minas Gerais Faculdade de Medicina Belo Horizonte MG Brasil Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil.
Objective:
This study aimed to evaluate extracellular vesicles (EVs) in a group of carriers of familial hypercholesterolemia (FH)-related genetic variants compared to those in family members without FH.
Subjects And Methods:
Annexin V-positive EVs (PS+-EVs), cardiomyocyte-derived EVs (CardioEVs), endothelial cell-derived EVs (EEVs), platelet-derived EVs (PEVs) and tissue factor-expressing EVs (TFEVs) were evaluated to compare individuals with FH and genetic variants (n = 16) and non-FH patients without genetic variants (n = 16).
Results:
Increased numbers of PS+-EVs, CardioEVs, EEVs and TFEVs were observed in the group c arrying genetic variants. Furthermore, patients with FH who did not use statins had higher counts of these same EVs than non-FH patients who did not use statins. These EVs were significantly correlated with low-density lipoprotein cholesterol (LDL-c) levels.
Conclusion:
The data suggest that EVs are related to FH and that their cellular origins could be related to cardiovascular complications commonly observed in this disease.
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