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Updated: Mar 12, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Efficient information extraction using LLMs and knowledge distillation: A study on HPV health communication.
Saadat Hasan Khan1, Kevin Lybarger2
1Department of Computer Science, George Mason University, Fairfax, Virginia, United States of America.
A new framework efficiently evaluates State Department of Health (DOH) websites for human papillomavirus (HPV) vaccine information quality. A fine-tuned RoBERTa Large model achieved high accuracy, enabling feasible assessment of DOH resources.
Area of Science:
- Computational Linguistics
- Public Health Informatics
- Health Communication
Background:
- State Department of Health (DOH) websites are key sources for human papillomavirus (HPV) health information, influencing public awareness and vaccination decisions.
- Systematic evaluation of the quality, completeness, and motivational impact of HPV vaccination information on these websites is crucial but challenging.
Purpose of the Study:
- To develop a computationally efficient framework for evaluating the quality and impact of HPV vaccination information on State DOH websites.
- To create a consolidated dataset from 48 DOH websites and an annotated dataset for model training and evaluation.
Main Methods:
- Development of a Knowledge Distillation framework using Large Language Models (LLMs) and RoBERTa Large.
- Creation of an annotated dataset (n=400) from 48 State DOH websites focusing on HPV and HPV vaccination.
- Training and evaluation of efficient student models, including fine-tuned RoBERTa Large, for content assessment.
Main Results:
- The fine-tuned RoBERTa Large model achieved a high F1 score of 0.74 on the test set, outperforming other student models.
- The best-performing model demonstrated performance close to the teacher model (F1=0.77).
- The model was successfully deployed for computationally feasible evaluation of State DOH website content.
Conclusions:
- A fine-tuned RoBERTa Large model provides an effective and efficient method for evaluating the quality of HPV vaccination information on State DOH websites.
- This framework supports systematic assessment, potentially improving public health communication strategies regarding HPV vaccination.
- The study highlights the utility of LLMs and distillation for analyzing health information repositories and discusses broader implications.
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