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Updated: Mar 12, 2026

Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma
Published on: April 20, 2018
Modeled Cost Analysis Using CPT/Medicare Rates and Approach Comparing Superficial Radiation Therapy Versus Mohs in
Igor Kapetanovic1, Adam Mattox, Ian Maher
1All authors are affiliated with the Department of Dermatology, University of Minnesota, Phillips-Wangsteen Building, Minneapolis, Minnesota.
Background:
Image-guided superficial radiotherapy (IGSRT) has been advocated for and advertised as having lower recurrence rates, lack of surgical scars, morbidity, and being more cost-effective in comparison with Mohs surgery (MMS).
Objective:
Evaluate and perform a modeled cost analysis using CPT/Medicare rates comparing IGSRT versus MMS in squamous cell carcinoma (SCC).
Materials And Methods:
The authors evaluated 3 exemplary and representative SCC lesions classified by stage (T1, T2, and Tis) and divided by anatomical location (head and neck/trunk and extremities).
Results:
Average cost of a Mohs procedure for both the head/neck and trunk/extremities ranged from $1,010.15 to $1,566.68 depending on the repair type. IGSRT had a wide variety and range in price from $1,450.49 to $10,244.93 for a 10-session regimen versus $2,058.74 to $ 25,510.58 for the recommended 25 session regimen. SRT delivery only accounts for 3.74% of the cost per session.
Conclusion:
Their results show that SRT can theoretically be 1.11 to 22.99 times more expensive regardless of MMS repair complexity. Overall time of the procedure is similar to twice as long but is also divided over the course of 10 to 25 days.
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