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Related Experiment Video

Updated: Jun 16, 2026

An Orthotopic Bladder Tumor Model and the Evaluation of Intravesical saRNA Treatment

An Orthotopic Bladder Tumor Model and the Evaluation of Intravesical saRNA Treatment

Published on: July 28, 2012

In Vivo Target Drug Enrichment Based on Spatiotemporal Acoustic Node Modulation (STANM) for Bladder Cancer Treatment.

Yimeng Su¹, Jingjing Wu^2,3, Zhaoyu Deng⁴

¹School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.

Advanced Materials (Deerfield Beach, Fla.)

|March 10, 2026

Summary

This study introduces spatiotemporal acoustic node modulation (STANM) to concentrate chemotherapy drugs at tumor sites. This novel method significantly enhances drug delivery, improving cancer treatment efficacy in preclinical models.

Keywords:

STANM cancer therapy spatially‐shifting acoustic radiation force target drug enrichment

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Last Updated: Jun 16, 2026

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Published on: July 28, 2012

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Published on: July 16, 2020

Area of Science:

Biomedical Engineering
Acoustic Physics
Oncology

Background:

Chemotherapy is a standard cancer treatment, but limited drug concentration at the tumor site reduces its effectiveness.
Developing methods to improve localized drug delivery is crucial for enhancing therapeutic outcomes and minimizing side effects.

Purpose of the Study:

To introduce and evaluate a novel in vivo drug enrichment technique using spatiotemporal acoustic node modulation (STANM).
To demonstrate the capability of STANM to significantly increase drug-loaded microparticle concentration at the target site.
To assess the therapeutic efficacy of STANM-enhanced chemotherapy in a preclinical cancer model.

Main Methods:

Development and application of spatiotemporal acoustic node modulation (STANM) to create a time-varying acoustic field.
Utilizing acoustic radiation forces to guide drug-loaded microparticles towards a focal point within the target tissue.
In vivo testing in mice bladders to compare tumor growth inhibition between STANM-enhanced chemotherapy and traditional chemotherapy.

Main Results:

STANM achieved an approximately 200-fold increase in microparticle concentration at the target site compared to control groups without acoustic enrichment.
In vivo studies demonstrated that target drug enrichment using STANM reduced tumor weight by 72.43% compared to conventional chemotherapy.
The method successfully concentrated drug-loaded microparticles in the target area, leading to significant tumor reduction.

Conclusions:

Spatiotemporal acoustic node modulation (STANM) represents a promising in vivo strategy for targeted drug enrichment in cancer therapy.
This acoustic-based method significantly enhances drug concentration at the tumor site, leading to improved therapeutic effects.
STANM offers a novel approach to overcome the limitations of insufficient drug delivery in traditional chemotherapy, paving the way for more effective cancer treatments.