Related Experiment Video

Updated: Mar 12, 2026

Intranasal Immunization and Milk Collection in Studies of Maternal Immunization in New Zealand White Rabbits Oryctolagus cuniculus
13:00

Intranasal Immunization and Milk Collection in Studies of Maternal Immunization in New Zealand White Rabbits Oryctolagus cuniculus

Published on: July 31, 2021

4.2K

The Impact of Milk Protein Allergy on Pediatric Otitis Media Incidence

Brittani P Kongala1, Gaayathri Varavenkataraman2, Grace Maley3

  • 1Florida State University College of Medicine, Tallahassee, Florida, USA.

The Laryngoscope
|March 10, 2026
PubMed

Insights

Children with milk protein allergy (MPA) have a higher incidence of otitis media (OM). Early diagnosis and dietary management of MPA are crucial for reducing OM risk and improving outcomes in pediatric patients.

Area of Science:

  • Pediatric Infectious Diseases
  • Allergy and Immunology
  • Otolaryngology

Background:

  • Otitis media (OM) is a common childhood infection.
  • Milk protein allergy (MPA) is a significant concern in pediatric populations.
  • Understanding the link between MPA and OM is crucial for effective management.

Purpose of the Study:

  • To investigate the association between milk protein allergy (MPA) and the incidence of otitis media (OM) in children.
  • To compare OM rates in children with and without MPA.
  • To identify potential risk factors for OM in pediatric patients.

Main Methods:

  • Retrospective cohort study using the TriNetX US database.
  • Inclusion of patients aged 2-17 years.
  • Propensity score matching to balance cohorts based on MPA presence.
  • Analysis of OM incidence (AOM, OME, CSOM) and frequency.

Main Results:

  • A significantly higher incidence of OM was observed in the MPA cohort (35.2%) compared to the non-MPA cohort (29.8%).
  • The odds ratio for OM in the MPA cohort was 1.28 (95% CI: 1.25-1.31, p < 0.001).
  • All types of OM were more prevalent in children with MPA.

Conclusions:

  • MPA is significantly associated with an increased risk of OM in children.
  • Early diagnosis and dietary management of MPA are vital for OM prevention.
  • Comprehensive care strategies can reduce the burden of OM in children with MPA.
Abstract

Keywords:
TriNetXallergymilk protein allergyotitis mediapediatrics

More Related Videos

Basophil Activation Test for Allergy Diagnosis07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

9.7K
Milk Collection in the Rat Using Capillary Tubes and Estimation of Milk Fat Content by Creamatocrit07:38

Milk Collection in the Rat Using Capillary Tubes and Estimation of Milk Fat Content by Creamatocrit

Published on: December 16, 2015

13.3K

Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

Overview
33.2K
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...
103
Overview of Protein Metabolism01:21

Overview of Protein Metabolism

Proteins are broken down into amino acids during digestion. Unlike fats and carbohydrates, which are stored for later use, proteins are not. Instead, amino acids are either used to produce ATP through oxidation or contribute to the creation of new proteins for the growth and repair of the body. Any surplus amino acids from the diet are converted into glucose or triglycerides rather than excreted.
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
4.4K
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
2.1K
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
1.5K