A new computational pipeline for multicompartment modeling of liver perfusion

Multicompartment porous media models are increasingly used to describe the hierarchical organization of hemodynamics in highly perfused tissues. The objective of this study is to develop a patient-specific multiscale finite element model for liver perfusion that accounts for interactions between large vessels and the microvasculature.

A multiscale framework is proposed that couples a 1D transport model for large hepatic vessels with a 3D multicompartment porous media model for microvascular perfusion. The geometry of the major hepatic vessels is explicitly included, enabling blood exchange between the vascular and porous compartments to be represented through interface flux conditions that prescribe both magnitude and direction of flow. A fully coupled numerical strategy is employed to ensure consistent interactions between scales and to improve computational efficiency and accuracy.

The simulations produce physiologically consistent pressure distributions and perfusion patterns. The coupled approach captures key features of hepatic hemodynamics and improves numerical robustness compared to sequential coupling strategies.

The proposed model provides a coherent multiscale description of liver perfusion by integrating patient-specific vascular geometry within a fully coupled framework. This approach represents a step forward in liver perfusion modeling, with potential applications in patient-specific medicine.