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Updated: Mar 12, 2026
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Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells
Published on: February 21, 2014
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Non-coding RNAs regulation in breast cancer pathogenesis
Bala Gur Dedeoglu1, Senem Noyan1, Kübra Nur Kaplan İlhan1
1Biotechnology Institute, Ankara University, Ankara, Türkiye.
Epigenomics
|March 10, 2026
Summary
Non-coding RNAs (ncRNAs) are key epigenetic regulators in breast cancer, influencing gene control and disease progression. Targeting these molecules offers new diagnostic and therapeutic strategies for precision oncology.
Area of Science:
- Epigenetics
- Molecular Biology
- Oncology
Background:
- Breast cancer is a complex disease driven by genetic and epigenetic alterations.
- Non-coding RNAs (ncRNAs) are crucial epigenetic regulators impacting gene expression.
- ncRNAs include microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs).
Purpose of the Study:
- To explore the role of ncRNAs in breast cancer's molecular heterogeneity.
- To highlight ncRNAs' functions in gene regulation and disease progression.
- To discuss ncRNAs as biomarkers and therapeutic targets in breast cancer.
Main Methods:
- Review of current literature on ncRNAs in breast cancer.
- Analysis of ncRNA interactions with cellular machinery.
- Examination of ncRNA expression patterns in different breast cancer subtypes.
Main Results:
- ncRNAs modulate transcriptional activity, chromatin accessibility, and gene stability.
- Aberrant ncRNA expression is linked to proliferation, metastasis, and therapeutic resistance.
- Distinct ncRNA signatures exist for triple-negative, HER2-positive, and hormone receptor-positive breast cancers.
Conclusions:
- ncRNAs are critical epigenetic regulators in breast cancer.
- ncRNAs show potential as minimally invasive biomarkers for early detection and monitoring.
- ncRNA-targeting therapies are advancing toward clinical application for precision oncology.
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