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Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
Published on: January 17, 2018
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Practical approach to managing pituitary gigantism.
Afiya Andrews1, Márta Korbonits2, Renuka P Dias3,4
1Centre for Endocrinology, William Harvey Research Institute, Queen Mary University of London Barts and The London School of Medicine and Dentistry, London, UK.
Archives of Disease in Childhood
|March 10, 2026
Summary
Pituitary gigantism is a rare endocrine disorder causing excessive growth. Early recognition and management are crucial for improving outcomes in affected children and adolescents.
Area of Science:
- Pediatric Endocrinology
- Growth Disorders
Background:
- Pituitary gigantism is a rare condition with significant morbidity and mortality if untreated.
- Diagnosis is challenging due to overlapping symptoms with normal puberty.
- It requires consideration in tall children with accelerated growth velocity.
Purpose of the Study:
- To support pediatricians in recognizing and assessing patients with pituitary gigantism.
- To summarize the etiology, investigations, management, and long-term outcomes.
- To provide a comprehensive overview for clinical practice.
Main Methods:
- Literature review on pituitary gigantism.
- Synthesis of information on diagnosis and management.
- Analysis of long-term outcomes.
Main Results:
- Key diagnostic criteria and differential diagnoses are outlined.
- Current management strategies including medical and surgical options are discussed.
- Long-term follow-up and potential complications are addressed.
Conclusions:
- Early diagnosis and intervention are vital for managing pituitary gigantism.
- A multidisciplinary approach is often necessary for optimal patient care.
- Understanding the full spectrum of outcomes is essential for long-term management.
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