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Learning to draw Fischer projections of molecules and understanding their relevance plays a crucial role in the visual depiction of organic molecules. A Fischer projection is a two-dimensional projection on a planar surface to simplify the three-dimensional wedge–dash representation of molecules. This is especially helpful in the case of molecules with multiple chiral centers that can be difficult to draw. Here, all the bonds of interest are represented as horizontal or vertical lines. While...
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A space truss is a three-dimensional counterpart of a planar truss. These structures consist of members connected at their ends, often utilizing ball-and-socket joints to create a stable and versatile framework. The space truss is widely used in various construction projects due to its adaptability and capacity to withstand complex loads.
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Structural steel products are created within a structural mill. The process begins with a beam blank that is reheated and then fed through a series of rollers. These rollers progressively shape the metal into its final form. Adjusting the spacings between the rollers allows for the production of different sections with the same nominal dimensions.
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Stereogenic P(V) platform construction via streamlined installation.

Jing-Ming Zhang1, Shi-Feng Tao1, Xing-Kai Zhao1

  • 1School of Chemistry and Materials Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China; State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Shanghai 200032, China.

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|March 10, 2026
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Summary
This summary is machine-generated.

This study introduces a streamlined method for creating complex phosphorus(V) stereocenters from simple precursors. The new approach simplifies the synthesis of molecules vital for medicines and agriculture, with potential for new fungicides.

Keywords:
Bioactive molecule synthesisFungicide discoveryPOCl(3)Phosphorus(V) stereocenterStreamlined installation

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Area of Science:

  • Organic Chemistry
  • Asymmetric Synthesis
  • Medicinal Chemistry

Background:

  • Fully heteroatom-substituted phosphorus(V) stereocenters are crucial in pharmaceuticals, agrochemicals, and catalysis.
  • Existing methods for creating these stereocenters often involve complex, multi-step syntheses, chiral auxiliaries, or resolution techniques, limiting efficiency and accessibility.
  • There is a need for more direct and robust catalytic asymmetric methods for synthesizing these valuable phosphorus(V) compounds.

Purpose of the Study:

  • To develop a streamlined and efficient strategy for installing fully heteroatom-substituted phosphorus(V) stereocenters.
  • To demonstrate the broad applicability of the new method using diverse nucleophiles and generating various stereocenters.
  • To showcase the utility of the protocol in synthesizing bioactive molecules and evaluating their potential applications, such as in agriculture.

Main Methods:

  • A novel, streamlined installation strategy starting from phosphorus oxychloride (POCl3).
  • Utilized thirteen distinct N-, O-, and S-based nucleophiles to react with POCl3.
  • Prepared six different types of phosphorus(V) stereocenters, with over 100 examples demonstrating the method's scope and reliability.

Main Results:

  • Successfully synthesized a wide array of fully heteroatom-substituted phosphorus(V) stereocenters using a simple and direct protocol.
  • The method proved general and reliable, evidenced by the preparation of over 100 distinct compounds.
  • Applied the protocol to the concise synthesis of twelve bioactive molecules and analogs, identifying two new potential fungicide candidates.

Conclusions:

  • The developed protocol offers an efficient and streamlined approach to access diverse phosphorus(V) stereocenters from readily available starting materials.
  • The synthetic method is versatile and reliable, facilitating the preparation of complex molecules for various applications.
  • Antifungal evaluations highlighted the significance of stereochemistry and identified promising new fungicide candidates, underscoring the practical utility of the research.