Therapeutic Potential of Green-Formulated Cerium Oxide Nanoparticles for Myocardial Infarction

This research focuses on creating innovative biogenic cerium oxide nanoparticles with multifunctional capabilities to improve treatment strategies for myocardial infarction and enhance cardiac care. The study specifically examined how curcumin-capped silver nanoparticles (Cur@CeO₂NPs) influence oxidative stress resulting from isoproterenol (ISO)-induced myocardial injury. A range of sophisticated characterization methods, such as UV-vis spectroscopy, FTIR, TEM, and XRD, verified that the environmentally produced Cur@CeO₂NPs had a cubic structure and demonstrated significant interactions with curcumin compounds. In this investigation, adult male Wistar rats were used and divided into three groups: a control group, one subjected to ISO injections, and a third group treated with Cur@CeO₂NPs. After the completion of the experiments, the levels of enzymes CK-MB and LDH were measured, and the expression of inflammatory markers HIF1α, TNF-α, and IL-6 was assessed through quantitative reverse transcription PCR (qRT-PCR). Histological changes in heart tissues resulting from ISO exposure were also evaluated using Hematoxylin and Eosin (H&E) staining. The results revealed a significant reduction in the inflammatory markers TNF-α and IL-6 in the Cur@CeO₂NPs treated group. This outcome validated the anti-inflammatory and antioxidant effects of Cur@CeO₂NPs, suggesting their protective role against cardiac injury. The study concludes that Cur@CeO₂NPs help restore redox balance and reduce inflammation, suggesting their potential protective properties. Nonetheless, further investigations are warranted to clarify their effects on inflammatory responses related to myocardial infarction.