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Bone Disorders01:29

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
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The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
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Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
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Related Experiment Video

Updated: Mar 12, 2026

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats
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Psychotropic medication use and bone loss in men: longitudinal study.

D Kavindi Weerasinghe1, Amanda L Stuart1, Julie A Pasco1,2,3

  • 1https://ror.org/02czsnj07Deakin University, School of Medicine, IMPACT, The Institute for Mental and Physical Health and Clinical Translation, Geelong, Australia.

Bjpsych Open
|March 11, 2026
PubMed
Summary

Psychotropic medication use is linked to bone loss in men with lower body mass index (BMI). This study highlights the need for bone health monitoring and preventive strategies in non-obese men using these medications.

Keywords:
Psychotropicanticonvulsantsantidepressantsantipsychoticsbone loss

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Area of Science:

  • Bone research
  • Endocrinology
  • Psychiatry

Background:

  • Psychotropic medication use is associated with reduced bone mineral density (BMD) and increased fracture risk.
  • Limited data exists on the longitudinal effects of psychotropic medications on bone loss over time.

Purpose of the Study:

  • To investigate the association between psychotropic medication use and longitudinal bone loss in men.
  • To explore the role of body mass index (BMI) as a potential effect modifier.

Main Methods:

  • Longitudinal study of 940 men (aged ≥20 years) with BMD measurements at baseline, 5, and 15 years.
  • Dual-energy X-ray absorptiometry (DXA) used for spine and hip BMD assessment.
  • Multivariable linear regression analyzed associations, considering BMI, lifestyle, and clinical factors.

Main Results:

  • Psychotropic use correlated with significant bone loss at the spine and hip over a median of 13.2 years.
  • Body mass index (BMI) modified the effect; bone loss was observed in non-obese men (25th and 50th BMI percentiles).
  • No significant association between psychotropic use and bone loss was found in men at the 75th BMI percentile.

Conclusions:

  • Psychotropic medication use is associated with accelerated bone loss, particularly in non-obese men.
  • Regular bone health monitoring and preventive interventions are crucial for men using psychotropic medications.
  • Further research may elucidate mechanisms and targeted interventions for bone protection.