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Synergistic protective effects of melatonin and selenium nanoparticles against cisplatin-induced nephrotoxicity
Faten Zahran1, Nashwa Barakat2, Ehab Ismail1
1Biochemistry Division, Chemistry Department, Faculty of Science, Zagazig University, Zagazig, Egypt.
Aim:
The objective of this study was to assess the protective effects of melatonin (Mel) and selenium nanoparticles (SeNPs) against cisplatin (Cis)-induced nephrotoxicity in rats.
Methods:
Sixty male rats were categorised into five groups: Control, Cis, Cis + Mel, Cis + SeNPs, and Cis + Mel + SeNPs. Kidney injury was evaluated at 5 and 11 days using biochemical markers, oxidative stress indicators, gene expression analysis as well as histopathological and immunohistochemical assessments.
Results:
The combined treatment of Mel + SeNPs significantly improved kidney function biomarkers, reduced MDA levels, increased the activities of SOD, CAT, and GSH, decreased the expression of Bax and IL-6, and increased the expression of Bcl-2, Nrf2, and HO-1 compared to Cis group (p < 0.05). The histological structure and protein expression profiles indicated the most significant enhancement in the combined therapy group, especially on day 11.
Conclusion:
The co-administration of Mel and SeNPs demonstrated a significant synergistic effect in protecting the kidneys from Cis-induced nephrotoxicity.
