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Pulmonary Nodular Lymphoid Hyperplasia Presenting With a Reversed Halo Sign.

Takafumi Yamano1, Shohei Yano1, Yuki Yoshida1

  • 1Department of Respiratory Medicine Osaka Red Cross Hospital Osaka Japan.

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|March 11, 2026
PubMed
Summary

The reversed halo sign, typically seen in lung diseases like organizing pneumonia, is now reported for the first time in pulmonary nodular lymphoid hyperplasia. This finding expands the known associations of this radiological sign in pulmonary conditions.

Keywords:
ground‐glass nodulepulmonary nodular lymphoid hyperplasiareversed halo sign

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Area of Science:

  • Pulmonology
  • Radiology
  • Pathology

Background:

  • The reversed halo sign is a radiological finding observed in various lung diseases.
  • It is most commonly associated with organizing pneumonia.
  • Its presence in pulmonary nodular lymphoid hyperplasia has not been previously documented.

Purpose of the Study:

  • To report the first instance of a reversed halo sign in a case of pulmonary nodular lymphoid hyperplasia.
  • To highlight the expanded spectrum of lung conditions associated with the reversed halo sign.

Main Methods:

  • Case presentation of a patient with pulmonary nodular lymphoid hyperplasia.
  • Radiological imaging analysis, focusing on the presence of the reversed halo sign.
  • Histopathological confirmation of pulmonary nodular lymphoid hyperplasia.

Main Results:

  • The study identified a case of pulmonary nodular lymphoid hyperplasia exhibiting the reversed halo sign on imaging.
  • This represents a novel association between the radiological finding and the specific lung pathology.

Conclusions:

  • Pulmonary nodular lymphoid hyperplasia should be considered in the differential diagnosis of lung diseases presenting with a reversed halo sign.
  • This case broadens the understanding of the radiological manifestations of pulmonary nodular lymphoid hyperplasia and the diagnostic utility of the reversed halo sign.