Usefulness of Regional Longitudinal Strain to Identify Transthyretin Amyloid Cardiomyopathy

Evaluation of the utility of regional longitudinal strain (LS) to identify transthyretin amyloid cardiomyopathy (ATTR-CM).

From 2016 to 2019 we enrolled 66 patients aged ≥70 years who underwent ^{99 m}Tc-labeled pyrophosphate scintigraphy and had enough information for 2-dimensional speckle-tracking echocardiography. Patients were divided into ATTR-CM group (n=37) and non-amyloid cardiomyopathy group (n=29). Basal inferior LS was significantly lower in the ATTR-CM group than in the non-amyloid cardiomyopathy group (4.6±3.9 vs. 10.7±5.4, P<0.01). ROC analysis showed that the basal inferior LS value was useful for identifying ATTR-CM (area under curve: 0.86).

Basal inferior LS value is the most useful for identifying ATTR-CM.