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Pancreatic Exocrine Function in Hospitalized Patients Following Acute Decompensated Heart Failure - An Observational
Masaru Hiki1, Takatoshi Kasai1,2,3,4, Akihiro Sato1
1Department of Cardiovascular Biology and Medicine, Juntendo University School of Medicine Tokyo Japan.
Circulation Reports
|March 11, 2026
Summary
Patients with acute decompensated heart failure (ADHF) show impaired pancreatic exocrine function (PEF). This finding suggests a potential link between heart failure severity and digestive health, impacting nutritional status.
Area of Science:
- Cardiology
- Gastroenterology
- Internal Medicine
Background:
- Acute decompensated heart failure (ADHF) can lead to multi-organ damage.
- The effect of ADHF on pancreatic exocrine function (PEF) and its contribution to malnutrition is not well understood.
Purpose of the Study:
- To investigate whether hospitalized patients with ADHF exhibit impaired PEF.
- To explore potential factors associated with reduced PEF in ADHF patients.
Main Methods:
- The study enrolled patients admitted to a cardiac intensive care unit.
- The N-benzoyl-L-tyrosyl-p-aminobenzoic acid (BT-PABA) test was used to assess PEF.
- Data from 51 patients were analyzed, comparing 33 ADHF patients with others.
Main Results:
- Patients hospitalized for ADHF had significantly lower urinary PABA excretion rates (PFD values) compared to other cardiovascular patients (52.4% vs. 66.4%, P=0.022).
- Reduced PFD values were associated with older age, higher HbA1c, impaired kidney function, low urinary volume, and ADHF hospitalization.
- Multiple regression identified reduced estimated glomerular filtration rate and ADHF hospitalization as key factors associated with poor PFD values.
Conclusions:
- Pancreatic exocrine function is impaired in hospitalized patients with ADHF.
- These findings suggest a potential link between ADHF and digestive impairment, warranting further research into nutritional status implications.
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