Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

1.3K
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
1.3K
Drug Discovery: Overview01:26

Drug Discovery: Overview

12.6K
Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
12.6K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

6.3K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
6.3K
Synthetic Biology02:55

Synthetic Biology

5.7K
Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
Golden rice is a genetically modified...
5.7K
Preclinical Development: Overview01:28

Preclinical Development: Overview

6.3K
Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
6.3K
Therapeutic Index01:13

Therapeutic Index

7.3K
The therapeutic index of a drug is a key parameter in pharmacology that quantifies the relative safety of a drug by calculating the ratio between the dose that causes toxicity in half the population (50%) to the dose that proves to be effective for half the population (50%). It provides a spectrum of doses for a particular drug ranging from effective to potentially toxic. To illustrate, consider an anticoagulant agent like warfarin. It possesses a narrow window within its therapeutic index to...
7.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Artificial Intelligence-Enabled Cardiac Function Estimation from Phone Videos of Echocardiograms.

medRxiv : the preprint server for health sciences·2026
Same author

A Single Reference-Guided Adaptation of Foundation Model Predictions for High-Performance Image Segmentation.

IEEE transactions on bio-medical engineering·2026
Same author

Integrated histopathology-transcriptomic biomarker enhances survival prediction in HNSCC patients treated with immunotherapy.

Translational oncology·2026
Same author

How is agentic AI changing how we do science?

Cell systems·2026
Same author

Influence of Huangjiu on flavor development in braised pork: A Flavoromics approach.

Food chemistry: X·2026
Same author

SyntheMol-RL: a flexible reinforcement learning framework for designing easily synthesizable antibiotics.

Molecular systems biology·2026
Same journal

A human-specific genetic modifier reconfigures large-scale cortical network dynamics underlying behavioral performance.

bioRxiv : the preprint server for biology·2026
Same journal

<i>Staphylococcus aureus</i> uses a eukaryotic-like uridyltransferase to make UDP-GlcNAc for cell wall synthesis.

bioRxiv : the preprint server for biology·2026
Same journal

Dynamic redistribution of eIF4F controls cap-dependent translation initiation.

bioRxiv : the preprint server for biology·2026
Same journal

When does additional information improve accuracy of RNA secondary structure prediction?

bioRxiv : the preprint server for biology·2026
Same journal

Normative brain-state trajectories reveal deviation from healthy aging in Alzheimer's disease.

bioRxiv : the preprint server for biology·2026
Same journal

Noradrenergic infraslow rhythm during sleep is the critical link between heart-rate dynamics and memory consolidation.

bioRxiv : the preprint server for biology·2026
See all related articles

Related Experiment Video

Updated: Mar 12, 2026

Virtual Agent for Real-Time Motivational Interviewing by Integrating Adaptive Nonverbal Behavior and Language Models
07:14

Virtual Agent for Real-Time Motivational Interviewing by Integrating Adaptive Nonverbal Behavior and Language Models

Published on: December 23, 2025

396

The Virtual Biotech: A Multi-Agent AI Framework for Therapeutic Discovery and Development.

Harrison G Zhang, Peter Eckmann, Jiacheng Miao

    Biorxiv : the Preprint Server for Biology
    |March 11, 2026
    PubMed
    Summary
    This summary is machine-generated.

    A novel AI team, the Virtual Biotech, accelerates drug discovery by integrating diverse data and expertise. This approach enhances target identification and therapeutic development, improving success rates and reducing adverse events.

    More Related Videos

    Haptic/Graphic Rehabilitation: Integrating a Robot into a Virtual Environment Library and Applying it to Stroke Therapy
    13:44

    Haptic/Graphic Rehabilitation: Integrating a Robot into a Virtual Environment Library and Applying it to Stroke Therapy

    Published on: August 8, 2011

    14.7K
    Author Spotlight: Enhancing Neurorehabilitation Through EEG, Motor Imagery, and Virtual Reality
    10:14

    Author Spotlight: Enhancing Neurorehabilitation Through EEG, Motor Imagery, and Virtual Reality

    Published on: May 10, 2024

    1.9K

    Related Experiment Videos

    Last Updated: Mar 12, 2026

    Virtual Agent for Real-Time Motivational Interviewing by Integrating Adaptive Nonverbal Behavior and Language Models
    07:14

    Virtual Agent for Real-Time Motivational Interviewing by Integrating Adaptive Nonverbal Behavior and Language Models

    Published on: December 23, 2025

    396
    Haptic/Graphic Rehabilitation: Integrating a Robot into a Virtual Environment Library and Applying it to Stroke Therapy
    13:44

    Haptic/Graphic Rehabilitation: Integrating a Robot into a Virtual Environment Library and Applying it to Stroke Therapy

    Published on: August 8, 2011

    14.7K
    Author Spotlight: Enhancing Neurorehabilitation Through EEG, Motor Imagery, and Virtual Reality
    10:14

    Author Spotlight: Enhancing Neurorehabilitation Through EEG, Motor Imagery, and Virtual Reality

    Published on: May 10, 2024

    1.9K

    Area of Science:

    • Computational biology and artificial intelligence in drug discovery.
    • Multi-omic data integration for therapeutic development.

    Background:

    • Drug discovery faces challenges integrating fragmented data, tools, and expertise across biological scales.
    • Current approaches often struggle with comprehensive analysis of diverse evidence.

    Purpose of the Study:

    • To introduce the Virtual Biotech, an AI agent team designed for end-to-end computational drug discovery.
    • To demonstrate the Virtual Biotech's capability in analyzing clinical trial data and evaluating drug targets.

    Main Methods:

    • Development of a Chief Scientific Officer agent to delegate tasks to specialized scientist agents.
    • Leveraging diverse data sources including statistical genetics, genomics, pathways, chemoinformatics, and clinical data.
    • Application of the Virtual Biotech to analyze clinical trial outcomes, evaluate cancer targets, and investigate trial failures.

    Main Results:

    • AI agents analyzed 55,984 clinical trials, identifying genomic features linked to drug target success.
    • Drugs targeting cell-type-specific genes showed significantly higher progression rates (Phase I to II: 40%, Phase IV: 48%) and lower adverse events (32%).
    • The Virtual Biotech successfully evaluated B7-H3 for lung cancer and proposed strategies for a terminated ulcerative colitis trial.

    Conclusions:

    • The Virtual Biotech enables transparent, efficient, and comprehensive multi-scale therapeutic analyses.
    • This AI-driven approach accelerates early-stage drug discovery workflows.
    • The system keeps human scientists involved while enhancing computational capabilities.