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Correlation between IL-17 levels and chronic urticaria: Systematic review and meta-analysis
Lin Wang1, Yuxu Yao1,2, Jun Zhou3
1Department of Dermatology, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Background:
Recent advances have elucidated the pivotal role of IL-17 in the pathogenesis of psoriasis, with breakthroughs in biologics modulating IL-17 signaling pathways. However, emerging evidence suggests a potential association between IL-17 and chronic urticaria (CU). Some studies have quantified IL-17 and related cytokines in CU cohorts to unravel their pathophysiologic contributions and therapeutic implications.
Objective:
This study conducted an evidence-based systematic review to evaluate the pathologic role of IL-17 in CU.
Methods:
Comprehensive searches were performed across Chinese and English biomedical databases, including CNKI, Wanfang, Sinomed, PubMed, and Web of Science, to collect clinical studies investigating the association between IL-17 and CU from database inception to December 31, 2024. Meta-analysis was performed by RevMan 5.4, with effect sizes calculated by a random-effects model.
Results:
A total of 37 eligible clinical studies were included, comprising 2,630 CU patients and 1,731 healthy controls. Meta-analysis revealed that serum IL-17 levels in CU patients were significantly higher than in controls, with a standardized mean difference of 2.71 (95% confidence interval, 2.28-3.15; Z = 12.12, P < .00001), demonstrating high statistical significance.
Conclusion:
As a key effector cytokine of the TH17 pathway, IL-17 exhibits a significant positive correlation with CU pathogenesis. Emerging clinical evidence suggests that IL-17 inhibitors may effectively treat antihistamine- and omalizumab-resistant chronic spontaneous urticaria.
