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Short Term Outcomes and Resource Utilization in Patients Admitted for Infective Endocarditis Who Develop Pericardial
Nameer Ascandar1, Sajog Kansakar2, Waqas Qureshi3
1Department of Internal Medicine, HCA Florida Sarasota Doctors Hospital, Sarasota, FL, USA.
Journal of Community Hospital Internal Medicine Perspectives
|March 11, 2026
Summary
Pericardial effusion (PCE) in infective endocarditis (IE) patients leads to worse outcomes and higher costs. However, draining the effusion during hospitalization reduces 30-day readmissions for these patients.
Area of Science:
- Cardiology
- Infectious Diseases
- Health Services Research
Background:
- Pericardial effusion (PCE) in infective endocarditis (IE) can worsen patient outcomes and increase healthcare resource use.
- Contemporary data on clinical outcomes, resource utilization, and readmission rates for IE patients who develop PCE is limited.
Purpose of the Study:
- To examine clinical outcomes, resource utilization, and 30-day readmission rates in patients admitted for IE who develop PCE.
- To compare outcomes between IE patients with and without PCE.
Main Methods:
- Utilized the Nationwide Readmissions Database (2016-2022) for adult IE admissions.
- Employed survey-weighted logistic and linear regression to analyze in-hospital mortality, clinical outcomes, costs, and 30-day readmissions.
- Risk-adjusted analysis was performed to assess the association of PCE with various outcomes.
Main Results:
- Of 162,694 IE patients, 1.8% developed PCE.
- PCE was associated with increased odds of in-hospital mortality, acute heart failure, cardiogenic shock, acute kidney injury, and need for mechanical circulatory support.
- PCE correlated with longer hospital stays and higher costs, but drainage during index admission lowered 30-day readmission rates.
Conclusions:
- PCE in IE patients is linked to poorer clinical outcomes, including mortality, longer hospital stays, and increased costs.
- Intervention to drain PCE during the initial hospitalization was associated with reduced 30-day non-elective readmissions.
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