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Matrix metalloproteinase-2 (MMP2) rs243865 polymorphism and target end-organ damage in difficult-to-control

Thuc Tri Nguyen1, An Viet Tran2, An Tuan Huynh2

  • 1Cho Ray Hospital, Ho Chi Minh City, Vietnam.

Peerj
|March 11, 2026
PubMed
Abstract

Insights

The matrix metalloproteinase-2 (MMP2) rs243865 polymorphism, particularly the C allele and CC genotype, is linked to target organ damage in difficult-to-control hypertension. This genetic factor may influence conditions like microalbuminuria and left ventricular hypertrophy.

Area of Science:

  • Genetics and Cardiovascular Disease
  • Molecular Biology and Hypertension Research
  • Clinical Genetics and Patient Outcomes

Background:

  • Difficult-to-control hypertension poses significant risks for cardiovascular events and target organ damage.
  • The matrix metalloproteinase-2 (MMP2) rs243865 polymorphism's role in severe hypertension is not well-established.
  • Understanding genetic predispositions can aid in managing complex hypertensive cases.

Purpose of the Study:

  • To investigate the characteristics of the MMP2 rs243865 polymorphism in Vietnamese patients with difficult-to-control hypertension.
  • To assess the association between this polymorphism and target organ damage (TOD) in this patient cohort.
  • To explore potential genetic markers for predicting TOD in challenging hypertension cases.

Main Methods:

  • Cross-sectional study of 70 patients with difficult-to-control hypertension in Southern Vietnam.
  • Sanger sequencing used to analyze MMP2 rs243865 polymorphism.
  • Target organ damage assessed across cardiac, renal, and vascular systems; logistic regression with FDR control applied for analysis.

Main Results:

  • The C allele (87.1%) and CC genotype (75.7%) predominated for MMP2 rs243865.
  • C allele and CC genotype were significantly associated with microalbuminuria, echocardiographic LVH, and renal TOD.
  • CC genotype also linked to combined cardiac TOD and lower odds of carotid artery stenosis.

Conclusions:

  • The MMP2 rs243865 polymorphism may play a role in the development of target organ damage in difficult-to-control hypertension.
  • Genetic variations in MMP2 could be potential biomarkers for assessing TOD risk.
  • Further research is warranted to confirm these findings and explore therapeutic implications.
Keywords:
Difficult-to-control hypertensionMMP-2 rs243865 polymorphismTarget organ damage

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