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Risk factor analysis for septic shock in female patients after mini-percutaneous nephrolithotripsy
Wen Deng1,2, Jiabiao Dai1, Jinkang Lin1
1Department of Urology, the First Affiliated Hospital of Nanchang University, Nanchang, China.
Translational Andrology and Urology
|March 11, 2026
Summary
Septic shock after mini-percutaneous nephrolithotripsy (mini-PCNL) is rare but deadly. Key risk factors in women include obesity, diabetes, immunosuppression, and preoperative urinary tract infections, necessitating proactive management.
Area of Science:
- Nephrology
- Urology
- Infectious Disease
Background:
- Septic shock following mini-percutaneous nephrolithotripsy (mini-PCNL) presents a low incidence but high mortality risk.
- Identifying risk factors for septic shock in female patients undergoing mini-PCNL is crucial for improving patient outcomes.
Purpose of the Study:
- To identify independent risk factors for septic shock in female patients undergoing mini-PCNL.
- To propose management strategies for preventing and treating septic shock post-mini-PCNL.
Main Methods:
- Retrospective analysis of 920 female patients who underwent mini-PCNL between January 2021 and March 2025.
- Logistic regression analyses (univariate and multivariate) were used to determine independent risk factors.
Main Results:
- 19 patients (2.07%) developed septic shock; 2 died from multiple organ dysfunction syndrome.
- Independent risk factors identified: BMI ≥28 kg/m² (OR=1.235), diabetes mellitus (OR=2.874), prior immunosuppressive agents (OR=1.815), and preoperative urinary tract infection (OR=1.217).
Conclusions:
- Obesity, diabetes, immunosuppression, and preoperative UTI are significant risk factors for septic shock after mini-PCNL in women.
- Recommendations include prophylactic antibiotics, strict glycemic control, and managing immune system disorders pre-procedure.
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