Related Experiment Video
Updated: Mar 12, 2026

Using In Vitro Live-cell Imaging to Explore Chemotherapeutics Delivered by Lipid-based Nanoparticles
Published on: November 1, 2017
Critical quality attributes of lipid nanoparticles and in vivo fate
Jiaxing Di1,2, Yuhong Xu3, Tonglei Li2
1School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China.
Abstract:
Lipid nanoparticles (LNPs) have emerged as versatile carriers for the delivery of genetic medicines and small-molecule drugs, offering desired benefits for therapeutic applications. Optimization of the treatment efficacy of nanocarriers necessitates a thorough understanding of the connection between pharmacokinetics and physicochemical properties. This review consolidates scientific efforts to elucidate how LNP's physicochemical attributes influence their in vivo fate, emphasizing particle size and shape, surface electric potential and ligand-binding chemistry. By examining the interplay between LNPs and biological barriers across various administration routes, this review provides insights into tailoring LNP properties for optimal delivery and reduced off-target effects. Recommendations for future research are provided to advance the study of LNP in vivo behaviors and offer a practical framework for optimizing in vivo performance through product design parameters.
Related Concept Videos
Modified-Release Drug Delivery Systems: Bioavailability
Factors Affecting Dissolution: Drug pKa, Lipophilicity and GI pH
A drug's pKa and the pH of the gastrointestinal (GI) tract play crucial roles...
Pharmacokinetics: Overview
Drug Distribution: Tissue Binding
For...

