Biomaterials-mediated sequential drug delivery: Emerging trends for wound healing

Area of Science:

• Biomaterials Science
• Regenerative Medicine
• Drug Delivery Systems

Background:

• Wound healing is a complex biological process often impaired in pathological conditions like diabetes and chronic inflammation.
• Pathological wounds exhibit microbial colonization, chronic inflammation, and poor regeneration, necessitating advanced wound care.
• Modern wound dressings have evolved into multifunctional systems for targeted drug delivery.

Purpose of the Study:

• To systematically review recent advancements in advanced wound dressings for drug delivery applications.
• To analyze material-driven drug release strategies from multiple perspectives.
• To provide insights into the clinical translation potential of these technologies.

Main Methods:

• Examination of structurally engineered controlled-release systems (bilayer architectures, layer-by-layer assembly, porous matrices).
• Analysis of intelligent stimulus-responsive mechanisms (physicochemical property modulation, swelling/degradation control, chemical bond engineering, crosslinking optimization).
• Critical assessment of cutting-edge technologies for drug delivery in wound healing.

Main Results:

• Detailed overview of advanced material designs for controlled drug release in wound dressings.
• Exploration of smart wound dressings responding to physiological stimuli for enhanced therapeutic effects.
• Identification of key strategies in material science for optimizing drug delivery efficacy.

Conclusions:

• Advanced wound dressings incorporating sophisticated drug delivery systems show significant promise for treating complex wounds.
• Material-driven strategies and intelligent responsive mechanisms are crucial for future wound care innovations.
• Further research and development are needed to facilitate the clinical translation of these advanced wound dressing technologies.