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Updated: Mar 12, 2026
Optimizing Extracellular Vesicle Delivery Using a Core-Sheath 3D-Bioprinted Scaffold for Chronic Wound Management
Published on: February 28, 2025
Biomaterials-mediated sequential drug delivery: Emerging trends for wound healing
Yuchuan Shi1, Shuaichen Guo1, Jiayi Tian1
1Department of Plastic Surgery, The First Hospital of China Medical University, Shenyang 110001, China.
Abstract:
Wound healing is a series of complex biological events that are tightly coordinated by the body. However, this physiological process is compromised in a pathological setting and underlie conditions including diabetic complications, infectious diseases and chronic inflammatory conditions. Clinically, this translates to multiple pathological features collectively exhibited (microbial colonization, chronic inflammation and impaired regenerative processes). Due to these pathological features, modern wound care approaches have changed from simple passive coverage products to advanced dressing systems which incorporate multifunctional therapies. To comprehensively elucidate recent advancements in advanced wound dressings for drug delivery applications, this review systematically examines material-driven drug release strategies through multiple analytical dimensions. The discussion encompasses structurally engineered controlled-release systems featuring bilayer architectures, layer-by-layer assembly techniques and porous matrix designs, as well as intelligent stimulus-responsive mechanisms based on physicochemical properties, including physical condition modulation, swelling/degradation behavior control, dynamic chemical bond engineering and crosslinking network optimization. Through critical analysis of these cutting-edge technologies, this article provides insightful perspectives on their clinical translation potential and future trajectories.
Insights
Advanced wound dressings offer multifunctional therapies to overcome compromised healing in chronic wounds. This review details material-driven drug release strategies for improved wound care and clinical translation.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Drug Delivery Systems
Background:
- Wound healing is a complex biological process often impaired in pathological conditions like diabetes and chronic inflammation.
- Pathological wounds exhibit microbial colonization, chronic inflammation, and poor regeneration, necessitating advanced wound care.
- Modern wound dressings have evolved into multifunctional systems for targeted drug delivery.
Purpose of the Study:
- To systematically review recent advancements in advanced wound dressings for drug delivery applications.
- To analyze material-driven drug release strategies from multiple perspectives.
- To provide insights into the clinical translation potential of these technologies.
Main Methods:
- Examination of structurally engineered controlled-release systems (bilayer architectures, layer-by-layer assembly, porous matrices).
- Analysis of intelligent stimulus-responsive mechanisms (physicochemical property modulation, swelling/degradation control, chemical bond engineering, crosslinking optimization).
- Critical assessment of cutting-edge technologies for drug delivery in wound healing.
Main Results:
- Detailed overview of advanced material designs for controlled drug release in wound dressings.
- Exploration of smart wound dressings responding to physiological stimuli for enhanced therapeutic effects.
- Identification of key strategies in material science for optimizing drug delivery efficacy.
Conclusions:
- Advanced wound dressings incorporating sophisticated drug delivery systems show significant promise for treating complex wounds.
- Material-driven strategies and intelligent responsive mechanisms are crucial for future wound care innovations.
- Further research and development are needed to facilitate the clinical translation of these advanced wound dressing technologies.
