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Sequential Dermoscopic, Histopathologic, and Immunopathologic Documentation of Regressing Seborrheic Keratosis: A
1Sumikawa Takada Dermatology Clinic Sapporo Japan.
None:
Seborrheic keratosis (SK) typically shows stable behavior, and spontaneous regression is rarely documented. We report a unique case of SK that underwent complete involution within 8 weeks. Sequential clinical and dermoscopic imaging demonstrated a transition from classical SK structures to red-blue homogeneous areas and, ultimately, to whitish regression zones. Histopathology revealed interface inflammation, keratinocyte degeneration, and epidermal remodeling. Immunohistochemistry confirmed a stepwise regression mechanism involving CD8+/TIA-1+ cytotoxic T-cell activation, cleaved caspase-3-mediated apoptosis, and keratinocyte-derived amyloid deposition. To our knowledge, this is the first case to demonstrate a fully time-resolved clinicodermoscopic-immunopathologic sequence of cytotoxic regression in SK.
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