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Benign Transient Hyperphosphatasemia in Adults: Case Report and Literature Review
Jose L Rodriguez Castro1, Grettel Gonzalez Garcia2, Daniel Heller1,3
1HCA Florida Aventura Hospital, Aventura, Florida.
Benign transient hyperphosphatasemia (BTH) is a rare condition causing temporary high alkaline phosphatase (ALP) levels, usually in children. This case highlights a rare adult presentation, emphasizing the need for increased awareness and diagnostic considerations in adults.
Area of Science:
- Endocrinology
- Clinical Biochemistry
Background:
- Benign transient hyperphosphatasemia (BTH) is characterized by temporary elevations in serum alkaline phosphatase (ALP) without underlying liver or bone disease.
- While commonly observed in children, BTH is infrequently reported in adults, with limited available data on its presentation and pathophysiology.
- The exact cause of BTH is unknown, but viral infections are suspected, and altered sialylation of ALP isoenzymes may reduce renal clearance.
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