Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Other Unique Bacteria01:18

Other Unique Bacteria

Magnetic bacteria exhibit a directed movement called magnetotaxis, driven by structures called magnetosomes. These magnetosomes consist of chains of magnetic particles made of either magnetite (Fe₃O₄) or greigite (Fe₃S₄) and are organized in a linear conformation by a protein scaffold within invaginations of the cell membrane. The bacteria align along the north–south magnetic field lines, much like a compass needle. They are typically microaerophilic or anaerobic and are commonly found near the...
Rapid Identification of Pathogens01:25

Rapid Identification of Pathogens

MALDI-TOF MS has transformed clinical microbiology by offering a rapid and reliable method for pathogen identification. The traditional approach to microbial identification typically involves time-consuming culture techniques and biochemical tests, which can delay the initiation of appropriate antimicrobial therapy. MALDI-TOF MS avoids these delays by using characteristic ribosomal protein mass patterns of microbial cells, enabling accurate species-level identification within minutes.Principle...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparative efficiency of Asian surgical systems in COVID-19 response: a multi-level longitudinal benchmarking study.

BMJ public health·2026
Same author

Rethinking the Structure of Global Surgical Education: Making the Case for ICOSET.

World journal of surgery·2026
Same author

Cultural and contextual dimensions of portfolio-based learning: A mixed-methods study.

Medical teacher·2026
Same author

Association between <i>Clostridioides difficile</i> infection and colorectal cancer incidence and mortality in a National Veterans Affairs Cohort.

medRxiv : the preprint server for health sciences·2026
Same author

Enterotoxigenic Bacteroides fragilis induces host genotype-specific colonic epithelial and immune responses in mice.

The Journal of infectious diseases·2026
Same author

A pro-carcinogenic bacterial toxin binds claudin-4 to cleave E-cadherin.

Nature·2026
Same journal

Predicting Chemotherapy Response from Staging Laparoscopy Images.

medRxiv : the preprint server for health sciences·2026
Same journal

Development and External Validation of a Machine Learning Model for 10-Year Ischemic Stroke Risk Prediction in Diverse Populations.

medRxiv : the preprint server for health sciences·2026
Same journal

MCH-Guard: Multimodal Machine Learning Framework for Risk Stratification of Cerebral Microhemorrhage Risk in the Alzheimer's Disease Neuroimaging Initiative.

medRxiv : the preprint server for health sciences·2026
Same journal

Genetic and maternal environmental contributions to estimated fetal weight at 20 weeks gestation compared with birthweight.

medRxiv : the preprint server for health sciences·2026
Same journal

Better immediate declarative memory is associated with forgetting during locomotor adaptation in chronic stroke and in older adults.

medRxiv : the preprint server for health sciences·2026
Same journal

An empirical Bayes framework for burden and dispersion association tests helps prioritize rare variants associated with Alzheimer's disease.

medRxiv : the preprint server for health sciences·2026
See all related articles

Related Experiment Video

Updated: Jun 29, 2026

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291
06:51

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291

Published on: December 10, 2016

13.4K

Clostridioides difficile Detection in a Human CRC Cohort.

S M Anderson, Z Cing, J L Drewes

    Medrxiv : the Preprint Server for Health Sciences
    |March 11, 2026
    PubMed
    Summary
    This summary is machine-generated.

    Clostridioides difficile is frequently detected in colorectal cancer (CRC) tumors, though in low abundance. Its presence correlates with biofilm-positive tissues, suggesting a role in CRC pathogenesis.

    More Related Videos

    A Protein Microarray Assay for Serological Determination of Antigen-specific Antibody Responses Following Clostridium difficile Infection
    09:12

    A Protein Microarray Assay for Serological Determination of Antigen-specific Antibody Responses Following Clostridium difficile Infection

    Published on: June 15, 2018

    10.5K
    Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection
    07:35

    Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection

    Published on: June 8, 2020

    7.5K

    Related Experiment Videos

    Last Updated: Jun 29, 2026

    Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291
    06:51

    Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291

    Published on: December 10, 2016

    13.4K
    A Protein Microarray Assay for Serological Determination of Antigen-specific Antibody Responses Following Clostridium difficile Infection
    09:12

    A Protein Microarray Assay for Serological Determination of Antigen-specific Antibody Responses Following Clostridium difficile Infection

    Published on: June 15, 2018

    10.5K
    Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection
    07:35

    Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection

    Published on: June 8, 2020

    7.5K

    Area of Science:

    • Microbiology
    • Oncology
    • Gastroenterology

    Background:

    • The gut microbiome's role in colorectal cancer (CRC) pathogenesis is under investigation.
    • Human CRC-derived Clostridioides difficile strains have induced colonic tumorigenesis in mice.
    • This study investigates C. difficile's contribution to human CRC development.

    Purpose of the Study:

    • To determine the prevalence and abundance of C. difficile in human CRC tumors versus paired normal tissues.
    • To explore the association between C. difficile detection and tumor biofilm status.
    • To analyze microbial community and functional differences in C. difficile-positive CRC cases.

    Main Methods:

    • Analysis of matched tumor/normal tissue samples from 108 CRC patients.
    • Detection of C. difficile using 16S rRNA sequencing, culture, and PCR.
    • Assessment of tumor biofilm presence and correlation with C. difficile detection.

    Main Results:

    • C. difficile was detected in 38% of individuals, with low relative abundance in tumors (0.01%) and normal tissues (0.006%).
    • C. difficile detection was significantly more prevalent in biofilm-positive tumors (p=0.04).
    • Exploratory analyses revealed taxonomic and functional pathway differences between C. difficile-positive and -negative groups.

    Conclusions:

    • C. difficile is frequently present in low abundance within the CRC tumor microbiome.
    • The bacterium may significantly impact the tumor microbiome's composition and function.
    • Findings suggest a potential role for C. difficile in CRC pathogenesis, particularly in biofilm-associated tumors.