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Updated: Mar 12, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
[Prostate cancer]
André N Vis1,2, Esther H J Hamoen3, Jean-Paul A van Basten4
1Amsterdam UMC, afd. Urologie, Amsterdam.
Abstract:
Prostate cancer is a common diagnosis and is usually established by PSA-driven diagnostics. The disease is often asymptomatic and does not affect the patient's life expectancy. Prostate cancer may follow an aggressive course with substantial mortality. Curative treatment options include robot-assisted radical prostatectomy and radiotherapy, sometimes in combination with hormonal therapy. Although these treatments are effective, they may be associated with urinary incontinence, erectile dysfunction, and urinary and gastrointestinal symptoms. Hormonal therapy has a broad spectrum of side-effects. The treatment of metastatic disease consists of hormonal therapy, in combinations or sequentially, and chemotherapy. Mortality in metastatic prostate cancer is high.
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