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Transcriptomics of Plasmodium vivax rosettingFIRST REVIEW ROUND - REVIEWERS COMMENTSREVIEWERS COMMENTS.

Catarina Bourgard1, Julia Weber Ferraboli2, Stefanie Costa Pinto Lopes3,4

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Investigating Plasmodium vivax rosetting, this study reveals key genes, including membrane proteins and PHIST proteins, are crucial for high rosetting rates in malaria parasites. These findings advance understanding of rosetting mechanisms.

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Area of Science:

  • Malariology
  • Genomics
  • Molecular Biology

Background:

  • Plasmodium vivax rosetting is a significant factor in malaria virulence and disease presentation.
  • The molecular underpinnings of P. vivax rosetting remain largely uncharacterized.
  • Comparative transcriptomics offers a pathway to elucidate rosetting mechanisms and their clinical implications.

Purpose of the Study:

  • To profile the transcription of P. vivax isolates exhibiting high versus low rosetting rates.
  • To identify specific genes and molecular pathways associated with P. vivax rosetting capacity.

Main Methods:

  • RNA sequencing (RNA-seq) was employed to compare transcriptomes.
  • Ten field isolates of P. vivax from the Brazilian Amazon were analyzed.

Main Results:

  • 492 differentially expressed genes were identified between high (HR) and low (LR) rosetting isolates.
  • Integral membrane and membrane-associated proteins, including PHIST proteins, were highlighted, comprising 10% of transcribed genes.
  • Upregulation of 6-cysteine gene family members, such as TRAG16 and MSP7-like, was observed in HR isolates.

Conclusions:

  • The study identifies key molecular players, particularly membrane proteins and specific gene families, involved in P. vivax rosetting.
  • These findings provide crucial insights into the molecular basis of P. vivax rosetting and its potential clinical relevance.