Engineered covalent organic framework-based nanosystem for strengthening pyroptosis-mediated tumor immunotherapy

Area of Science:

• Biomaterials Science
• Nanotechnology
• Immunotherapy

Background:

• Pyroptosis-based nanomedicine can convert immunosuppressive "cold tumors" into immunogenic "hot tumors", advancing cancer immunotherapy.
• Developing selective nanosystems to induce pyroptosis effectively remains a significant challenge in tumor treatment.

Purpose of the Study:

• To systematically review recent advancements in covalent organic framework (COF) nanomedicine for inducing pyroptosis.
• To explore COF strategies for modulating the tumor immune microenvironment and enhancing immunotherapy outcomes.
• To analyze challenges and future directions in COF material design for cancer therapy.

Main Methods:

• Review of current literature on COF nanomedicine and pyroptosis induction.
• Analysis of COF structural properties and their mechanisms in triggering pyroptosis.
• Examination of COFs used alone or in combination with other therapeutic agents.

Main Results:

• COFs offer tunable structures, high loading capacity, and biocompatibility, making them ideal for pyroptosis-based nanomedicine.
• COF nanomedicine strategies effectively induce pyroptosis, reprogramming the tumor microenvironment.
• Combined COF and drug therapies show enhanced pyroptosis induction and anti-tumor effects.

Conclusions:

• COF nanomedicine presents a promising platform for pyroptosis-based cancer immunotherapy.
• Further research into structural design and functional integration of COFs is crucial for clinical translation.
• Interdisciplinary approaches can accelerate the development of advanced COF materials for enhanced cancer immunotherapy.