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Incorporating The Patient Voice Into Attribute And Level Selection For A Preference Study: A Qualitative Study In Non-muscle Invasive Bladder Cancer.

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Incorporating The Patient Voice Into Attribute And Level Selection For A Preference Study: A Qualitative Study In Non-muscle Invasive Bladder Cancer.

Related Experiment Video

Culture of Bladder Cancer Organoids as Precision Medicine Tools

Culture of Bladder Cancer Organoids as Precision Medicine Tools

Published on: December 28, 2021

Incorporating the Patient Voice into Attribute and Level Selection for a Preference Study: A Qualitative Study in

Brad Mason¹, Anthony Eccleston², Lara Ayala-Nunes³

¹Adelphi Values Patient-Centered Outcomes, Bollington, UK. brad.mason@omc.com.

|March 11, 2026

View abstract on PubMed

Summary

This summary is machine-generated.

Patients with high-risk non-muscle invasive bladder cancer (HR-NMIBC) prioritize treatment efficacy and safety. Understanding these preferences is crucial for developing new therapies and patient-centered care strategies.

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Area of Science:

Oncology
Patient-Reported Outcomes
Health Services Research

Background:

Current standard of care for high-risk non-muscle invasive bladder cancer (HR-NMIBC) involves Bacillus Calmette-Guerin (BCG) post-transurethral resection of bladder tumor (TURBT).
Emerging therapies, including immune checkpoint inhibitors (ICIs) in combination with BCG, offer new treatment avenues for HR-NMIBC patients.
Patient preference studies are vital for understanding trade-offs in current and emerging treatments, informing patient-centered care.

Purpose of the Study:

To elicit treatment priorities from patients with HR-NMIBC.
To evaluate a preliminary list of attributes and levels for a patient preference survey.
To gather qualitative insights into decision-making drivers for HR-NMIBC treatments.

Main Methods:

A targeted literature review identified an initial list of 11 treatment attributes.
Semi-structured, multi-method telephone interviews were conducted with 12 HR-NMIBC patients in the USA.
Concept elicitation, cognitive debriefing, and rating/ranking exercises assessed patient priorities and perspectives on treatment attributes.

Main Results:

Treatment efficacy, specifically event-free survival, was the most significant attribute for all patients.
The risk of serious or life-threatening events was also a highly important consideration for patients.
Bladder-related issues and administration preferences (route, frequency) were key factors in treatment choices.

Conclusions:

This study provides novel qualitative data on patient preferences for future HR-NMIBC treatments.
Findings will guide the selection and framing of attributes for an upcoming benefit-risk preference study.
Further research is needed to quantify patient trade-offs regarding treatment administration, benefits, and risks.