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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Leaky by Design: Unlocking Polymersome Permeability Using Moderately Hydrophobic Polymer Blocks.

Wencui Zhang1, Anabella P Rosso2, Yang Yu1

  • 1Equipe Chimie des Polymères, Institut Parisien de Chimie Moléculaire (UMR-CNRS 8232), Sorbonne Université, Paris 75 252, France.

Langmuir : the ACS Journal of Surfaces and Colloids
|March 11, 2026
PubMed
Summary
This summary is machine-generated.

Polymer vesicles made with poly(butylene oxide) show natural membrane permeability to small molecules. This breakthrough allows for simpler, permeable nanoreactors for enzyme catalysis without added channels.

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Area of Science:

  • Polymer Chemistry
  • Materials Science
  • Biomimetic Systems

Background:

  • Polymersome nanoreactors are key for compartmentalized catalysis and biomimetic systems.
  • Achieving intrinsic membrane permeability in polymersomes typically requires artificial components like channel proteins.
  • Previous research focused on enzyme encapsulation, with limited success in creating inherently permeable vesicles.

Purpose of the Study:

  • To develop polymersome nanoreactors with inherent membrane permeability.
  • To demonstrate the utility of poly(butylene oxide) in creating permeable polymer vesicles.
  • To showcase the application of these permeable vesicles in enzyme-mediated catalysis.

Main Methods:

  • Synthesis and characterization of diblock and triblock copolymers with poly(butylene oxide) and poly(glycidol).
  • Self-assembly of copolymers into polymer vesicles.
  • Demonstration of inherent small molecule permeability using various assays.
  • Encapsulation of a model enzyme (horseradish peroxidase) and assessment of substrate/product transport.

Main Results:

  • Polymer vesicles composed of poly(butylene oxide) exhibit inherent permeability to small molecules.
  • This permeability is attributed to the moderate hydrophobicity and membrane hydration of poly(butylene oxide).
  • Enzyme-loaded vesicles successfully facilitated enzyme-mediated catalysis due to permeable substrates and products.

Conclusions:

  • Polymer vesicles with poly(butylene oxide) offer a novel platform for inherently permeable nanoreactors.
  • This strategy simplifies the design of nanoreactors, eliminating the need for artificial porogenic components.
  • The developed permeable polymersomes are applicable to a broad range of enzymes and proteins for catalysis.