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Updated: Mar 13, 2026
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Author Spotlight: Genetic Profiling for Fluorouracil Response in Gastric Cancer
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Association Between Folate Status and Risk of Cervical Cancer: A Systematic Review, Dose-Response Meta-analysis, and
Yan Hua1, Yuanxing Li2, Hong Qin1
1Departments of Obstetrics and Gynecology, Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, 030001, China.
Nutrition Reviews
|March 11, 2026
Summary
Low folate levels increase cervical cancer (CC) risk. Folate supplementation may reduce CC risk and aid regression of cervical intraepithelial neoplasia (CIN).
Area of Science:
- Gynecology
- Oncology
- Nutritional Science
Background:
- Cervical cancer (CC) is a significant global health concern for women.
- Folate is vital for DNA synthesis and methylation, but its role in cervical carcinogenesis is unclear.
Purpose of the Study:
- To investigate the link between folate deficiency and cervical cancer risk.
- To examine the effect of folate supplementation on cervical intraepithelial neoplasia (CIN) regression.
Main Methods:
- Comprehensive literature search of PubMed and Ovid databases.
- Included 25 studies with 14,304 participants; data extracted via standardized protocol.
- Utilized meta-analysis, dose-response analysis, and Mendelian randomization.
Main Results:
- Low dietary, serum, and red blood cell (RBC) folate levels correlated with higher CIN/CC risk.
- Folate supplementation (240–280.5 μg/day) associated with up to 26% risk reduction for CIN/CC.
- Increased serum and RBC folate showed significant risk reduction for CIN/CC.
Conclusions:
- Higher folate intake and serum/RBC folate concentrations may reduce CIN/CC risk.
- Folate supplementation is important for cervical cancer prevention strategies.
- Further research supports folate's role in reducing cervical cancer incidence.
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