Related Experiment Video

Updated: Mar 13, 2026

Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds
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Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds

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Role of alpha-terpineol modulating pathway nitric oxide into coronary tissues: A confluent mechanism for the

Emanuel Tenório Paulino1, Hira Muzammel2, Lucindo José Quintans-Júnior3

  • 1Institute of Pharmaceutical Science, Federal University of Alagoas, Brazil; Unité Nanoregenerative Medicine, Université de Strasbourg, France.

Tissue & Cell
|March 11, 2026
PubMed

Insights

Alpha-terpineol (TPN) promotes heart protection by relaxing coronary arteries and stimulating endothelial cell growth, independent of the endothelium. This compound offers potential in preventing heart damage from reduced oxygen supply.

Area of Science:

  • Cardiovascular Research
  • Pharmacology
  • Molecular Biology

Background:

  • Coronary arteries are vital for heart oxygen and nutrient supply.
  • Myocardial infarction is a prevalent global disease involving ischemia-reperfusion injury.
  • Alpha-terpineol (TPN) has demonstrated cardioprotective effects.

Purpose of the Study:

  • To investigate the vascular effects of alpha-terpineol (TPN) on coronary vessels.
  • To determine if TPN can modulate coronary artery tone and function.

Main Methods:

  • Utilized in vivo, in vitro, and in silico approaches.
  • Included histopathology of coronary arteries, myograph-based perfusion studies, endothelial cell culture, and molecular docking.

Main Results:

  • TPN induced vasorelaxation independently of endothelial presence.
  • TPN promoted endothelial cell growth via nitric oxide (NO) production.
  • TPN demonstrated direct vasodilatory action and restored endothelial cell growth.

Conclusions:

  • TPN modulates vascular function, acting as a vasodilator.
  • TPN can prevent hypoxia/anoxia by ensuring adequate heart perfusion.
  • TPN shows potential for cardioprotection against myocardial infarction.
Abstract

Keywords:
Alpha-terpineolCardioprotectionCoronary arteryVasodilator

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