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Updated: May 26, 2026

Synthesis of Cd-free InP/ZnS Quantum Dots Suitable for Biomedical Applications
Published on: February 6, 2016
The water-soluble red CsPbI3 perovskite quantum dot "on-off-on" fluorescence sensor for the detection of Cu2+ and
Mengjiao Pang1, Yanjie Wang1, Zengcheng Du1
1College of Pharmacy, Guangdong Pharmaceutical University, Guangzhou Higher Education Mega Center, Guangzhou 510006, PR China.
Abstract:
In this study, a water-soluble perovskite quantum dot (PQDs) based on CsPbI3 "on-off-on" fluorescent probe was successfully constructed. The probe exhibits red fluorescence emission at 660 nm under 465 nm excitation, and the response mechanism of Cu2+-induced fluorescence quenching (OFF) and D-penicillamine (D-PA) triggered fluorescence recovery (ON) is realized. In addition, the dual target detection platform of both copper ions (Cu2+) and D-PA was established. Quantitative analysis showed that the detection linearity range was 0.5-15 μM (LOD = 0.21 μM) for Cu2+ and 0.4-60 μM (LOD = 16.7 nM) for D-PA. Meanwhile, D-PA can be semi-quantitatively measured based on the change in solution color. The fluorescent probe provides a fast response time, high sensitivity, and convenient solution for real-time detection of Cu2+ and D-PA. And it was applied in the determination of D-PA in serum samples with satisfactory results. It is particularly noteworthy that the synthesized perovskite quantum dots exhibit excellent stability in the aqueous environment, which provides a new strategy for expanding the application of perovskite materials in the field of biomedical analysis.
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