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Real-Time Assessment of Dentinal Fluid Flow Reduction by Desensitising Agents Using Subnanolitre Flow Measuring
Soyeon Kim1, Satoshi Yamaguchi2, In-Bog Lee3
1Department of Oral Anatomy and Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Republic of Korea.
International Dental Journal
|March 11, 2026
Summary
Several desensitizing toothpastes effectively reduce dentinal permeability, comparable to professional fluoride varnish treatments. Real-time fluid flow measurements validated their efficacy in occluding dentinal tubules.
Area of Science:
- Dentistry
- Biomaterials Science
- Fluid Dynamics
Background:
- Dentin hypersensitivity is a common clinical concern.
- Effective occlusion of dentinal tubules is crucial for managing sensitivity.
- Novel methods are needed to functionally assess desensitizing agents.
Purpose of the Study:
- To compare the dentinal tubule-occluding efficacy of various desensitizing toothpastes and a sodium fluoride varnish.
- To evaluate the use of a subnanolitre scaled fluid flow measuring device (NFMD) for real-time assessment.
Main Methods:
- Bovine dentin specimens were treated with four desensitizing toothpastes, a sodium fluoride varnish, and distilled water.
- Real-time dentinal fluid flow (DFF) was measured using the NFMD under simulated pulpal pressure.
- Surface morphology was examined using field-emission scanning electron microscopy (FE-SEM).
Main Results:
- Significant differences in dentinal fluid flow reduction were observed among treatments (P < .001).
- Bamboo Salt, Sensodyne, and Colgate toothpastes showed greater efficacy than the sodium fluoride varnish.
- FE-SEM confirmed substantial tubule occlusion for Bamboo Salt and Sensodyne, and minimal occlusion for others.
Conclusions:
- Desensitizing toothpastes can reduce dentinal permeability to levels comparable to sodium fluoride varnish.
- Real-time fluid flow measurement provides functional validation of dentinal tubule occlusion.
- Understanding formulation interactions aids product selection for dentin hypersensitivity.
