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A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model
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Antithrombin III as a potentially predictive biomarker for post-stroke depression
Fengyun Wang1, Yongtao Yu2, Xiaoxuan Zhang3
1Department of Neurology, the Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi, 214023, China.
Summary
Antithrombin III (ATIII) activity changes during stroke treatment may predict post-stroke depression (PSD). Higher ATIII levels correlate with increased depressive symptoms and inflammation in PSD patients, indicating its potential as a biomarker.
Area of Science:
- Neuroscience
- Immunology
- Biochemistry
Background:
- Antithrombin III (ATIII) possesses anti-inflammatory properties beyond its role in coagulation.
- Post-stroke depression (PSD) is a common complication following ischemic stroke.
Purpose of the Study:
- To investigate the association between Antithrombin III (ATIII) and post-stroke depression (PSD).
- To evaluate ATIII's potential as a predictive biomarker for PSD.
Main Methods:
- A longitudinal observational study enrolled 120 PSD patients and 100 ischemic stroke controls.
- Clinical parameters, including ATIII activity, were assessed during hospitalization.
- PSD patients underwent psychological assessments (HAMD-24) at 3, 9, and 15 months post-discharge.
Main Results:
- PSD patients showed significantly higher changes in ATIII activity compared to controls.
- Increased ATIII activity changes correlated with higher HAMD-24 scores and increased pro-inflammatory markers.
- ATIII levels interacted with C-reactive protein to influence depressive symptom severity.
Conclusions:
- Elevated ATIII activity during stroke treatment may predict PSD risk.
- Higher ATIII levels are linked to more severe depressive symptoms and inflammation in PSD patients.
- ATIII shows potential as a biomarker for predicting and assessing PSD severity.
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