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Updated: Mar 13, 2026

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Antithrombin III as a potentially predictive biomarker for post-stroke depression

Fengyun Wang1, Yongtao Yu2, Xiaoxuan Zhang3

  • 1Department of Neurology, the Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi, 214023, China.

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
|March 11, 2026
PubMed

Insights

Antithrombin III (ATIII) activity changes during stroke treatment may predict post-stroke depression (PSD). Higher ATIII levels correlate with increased depressive symptoms and inflammation in PSD patients, indicating its potential as a biomarker.

Area of Science:

  • Neuroscience
  • Immunology
  • Biochemistry

Background:

  • Antithrombin III (ATIII) possesses anti-inflammatory properties beyond its role in coagulation.
  • Post-stroke depression (PSD) is a common complication following ischemic stroke.

Purpose of the Study:

  • To investigate the association between Antithrombin III (ATIII) and post-stroke depression (PSD).
  • To evaluate ATIII's potential as a predictive biomarker for PSD.

Main Methods:

  • A longitudinal observational study enrolled 120 PSD patients and 100 ischemic stroke controls.
  • Clinical parameters, including ATIII activity, were assessed during hospitalization.
  • PSD patients underwent psychological assessments (HAMD-24) at 3, 9, and 15 months post-discharge.

Main Results:

  • PSD patients showed significantly higher changes in ATIII activity compared to controls.
  • Increased ATIII activity changes correlated with higher HAMD-24 scores and increased pro-inflammatory markers.
  • ATIII levels interacted with C-reactive protein to influence depressive symptom severity.

Conclusions:

  • Elevated ATIII activity during stroke treatment may predict PSD risk.
  • Higher ATIII levels are linked to more severe depressive symptoms and inflammation in PSD patients.
  • ATIII shows potential as a biomarker for predicting and assessing PSD severity.
Abstract

Keywords:
Antithrombin IIIC-reactive proteinFollow-upInflammationPost-stroke depression

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