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Related Concept Videos

Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

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Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
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Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

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Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
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Urinary Tract Calculi VI: Surgical Management01:25

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Procedures for Kidney StonesMedical intervention is necessary when kidney stones or renal calculi are too large to pass spontaneously (typically greater than 5 millimeters) when stones are accompanied by symptomatic infection (such as fever or pyelonephritis), when they impair kidney function, or when they cause persistent symptoms like severe pain, nausea, or urinary retention. Additionally, patients with only one kidney or those who cannot be treated with medical management also require...
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Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

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Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
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Atherosclerosis III: Management01:26

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Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
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The diagnosis of renal calculi involves several imaging techniques, including non-contrast CT scans and ultrasound. These methods help visualize kidney stones, assess their size and location, and detect possible obstructions. Additionally, Measuring urine pH is useful for diagnosing specific stone types, such as struvite (alkaline pH) and uric acid stones (acidic pH). Cystine stones are primarily linked to cystinuria, a genetic condition. A urinalysis helps detect blood in the urine (hematuria)...
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Related Experiment Video

Updated: Mar 13, 2026

Reduction of Radiation Exposure during Endovascular Treatment of Peripheral Arterial Disease Combining Fiber Optic RealShape Technology and Intravascular Ultrasound
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Intravascular Lithotripsy for Peripheral Artery Calcification: 30-Day and 6-Month Outcomes from the RESTORE ATK

Marianne Brodmann1, Oliver Schlager2, Martin Werner3

  • 1Division of Angiology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.

Journal of Vascular and Interventional Radiology : JVIR
|March 11, 2026
PubMed
Summary
This summary is machine-generated.

Intravascular lithotripsy (IVL) effectively treated calcified above-the-knee lesions in peripheral artery disease patients. The SEISMIQ IVL system showed no major adverse events and sustained clinical improvement.

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Area of Science:

  • Cardiovascular Interventions
  • Peripheral Artery Disease Treatment
  • Medical Device Technology

Background:

  • Calcified femoropopliteal lesions pose significant challenges in peripheral artery disease (PAD) management.
  • Traditional treatment methods for severe calcification can be limited, increasing procedural risks.
  • Intravascular lithotripsy (IVL) offers a novel approach to treat complex calcified lesions.

Purpose of the Study:

  • To evaluate the safety and effectiveness of the SEISMIQ Intravascular Lithotripsy (IVL) System.
  • To assess IVL's efficacy in treating calcified above-the-knee (ATK) lesions in PAD patients.
  • To determine the rate of major adverse events (MAE) and clinical outcomes post-IVL treatment.

Main Methods:

  • Prospective, single-arm RESTORE ATK study involving 95 patients with moderate to severe calcified ATK lesions.
  • Treatment with the SEISMIQ IVL system without adjunctive drug-eluting technology.
  • Primary endpoints: <50% residual diameter stenosis and 30-day MAE (death, CD-TLR, major amputation).

Main Results:

  • All patients achieved <50% residual stenosis post-IVL, with a mean residual stenosis of 21.2%.
  • No major adverse events (MAE) were reported within 30 days.
  • At 6 months, target lesion patency was 66.3%, freedom from CD-TLR was 97.9%, and significant Rutherford classification improvement was observed.

Conclusions:

  • The SEISMIQ IVL system is safe and effective for treating calcified ATK lesions in PAD.
  • IVL successfully reduced calcific stenoses with minimal complications.
  • Sustained clinical improvement was demonstrated through 6-month follow-up.