Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Carbohydrate Metabolism01:36

Carbohydrate Metabolism

14.8K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
14.8K
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

5.8K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
5.8K
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

5.3K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
5.3K
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

4.1K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
4.1K
Insulin: Biosynthesis, Chemistry, and Preparation01:25

Insulin: Biosynthesis, Chemistry, and Preparation

1.8K
The endoplasmic reticulum (ER) of pancreatic β-cells synthesizes preproinsulin, which consists of a signal peptide, A and B chains, and a C-peptide. Preproinsulin is then cleaved and folded into proinsulin, which translocates to the Golgi apparatus for sorting and packaging into secretory granules. In these granules, enzymatic clipping generates insulin and C-peptide.
Damage or functional impairment of β-cells inhibits insulin production, leading to diabetes. Diabetes treatment...
1.8K
Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

2.2K
After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
2.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The effect of rapid improvement of blood glucose level on diabetic neuropathy in Korean people with diabetes mellitus.

Diabetes research and clinical practice·2026
Same author

Conformal SiNx Coating on Carbon Nanotubes via Transient UV-Ozone Functionalization and Two-Step Atomic Layer Deposition.

Materials (Basel, Switzerland)·2026
Same author

Efficacy and safety of anagliptin added to metformin and empagliflozin 25 mg in patients with type 2 diabetes: a 24-week randomized, double-blind, placebo-controlled phase 3 trial with 28-week open-label extension.

Diabetes research and clinical practice·2026
Same author

Genetic and Lifestyle Factors Influence High 1-Hour Plasma Glucose, a Predictor of Type 2 Diabetes Mellitus.

Diabetes & metabolism journal·2026
Same author

Mitochondria as Epigenetic Regulators of β-Cell Identity and Plasticity: A Metabolo-Epigenetic Perspective.

Cells·2026
Same author

Is high insulin protective or detrimental? Mathematical modeling reveals the base of the iceberg.

American journal of physiology. Endocrinology and metabolism·2026

Related Experiment Video

Updated: Mar 13, 2026

Analysis of Beta-cell Function Using Single-cell Resolution Calcium Imaging in Zebrafish Islets
08:50

Analysis of Beta-cell Function Using Single-cell Resolution Calcium Imaging in Zebrafish Islets

Published on: July 3, 2018

15.4K

Redefining β-Cell Function in Type 2 Diabetes Mellitus: From Comprehensive Assessment to Precision Medicine.

YongKyung Kim1, Joon Ha2, Jun Sung Moon1,3

  • 1Institute of Medical Science, Yeungnam University College of Medicine, Daegu, Korea.

Diabetes & Metabolism Journal
|March 11, 2026
PubMed
Summary

Assessing pancreatic beta-cell function is crucial for managing type 2 diabetes mellitus (T2DM). This review details methods to evaluate beta-cell capacity, aiding diagnosis and treatment for better patient outcomes.

Keywords:
Diabetes mellitus, type 2Diagnostic techniques and proceduresGlucose tolerance testInsulin-secreting cellsPrecision medicine

More Related Videos

Assessing Replication and Beta Cell Function in Adenovirally-transduced Isolated Rodent Islets
09:31

Assessing Replication and Beta Cell Function in Adenovirally-transduced Isolated Rodent Islets

Published on: June 25, 2012

14.5K
A High-content In Vitro Pancreatic Islet β-cell Replication Discovery Platform
09:35

A High-content In Vitro Pancreatic Islet β-cell Replication Discovery Platform

Published on: July 16, 2016

11.7K

Related Experiment Videos

Last Updated: Mar 13, 2026

Analysis of Beta-cell Function Using Single-cell Resolution Calcium Imaging in Zebrafish Islets
08:50

Analysis of Beta-cell Function Using Single-cell Resolution Calcium Imaging in Zebrafish Islets

Published on: July 3, 2018

15.4K
Assessing Replication and Beta Cell Function in Adenovirally-transduced Isolated Rodent Islets
09:31

Assessing Replication and Beta Cell Function in Adenovirally-transduced Isolated Rodent Islets

Published on: June 25, 2012

14.5K
A High-content In Vitro Pancreatic Islet β-cell Replication Discovery Platform
09:35

A High-content In Vitro Pancreatic Islet β-cell Replication Discovery Platform

Published on: July 16, 2016

11.7K

Area of Science:

  • Endocrinology
  • Metabolic Diseases
  • Diabetes Research

Background:

  • Type 2 diabetes mellitus (T2DM) is a growing global health concern.
  • Pancreatic beta-cell dysfunction is a key factor in T2DM pathogenesis.
  • Accurate assessment of beta-cell function is clinically challenging but vital.

Purpose of the Study:

  • To provide a comprehensive technical overview of beta-cell function assessment methodologies.
  • To examine the strengths and limitations of various assessment tools.
  • To explore the clinical implications for T2DM diagnosis, treatment, and remission.

Main Methods:

  • Review of conventional methods (fasting indices, glucose tolerance tests).
  • Analysis of advanced techniques (mathematical modeling, AI-driven approaches).
  • Evaluation of methodological strengths, limitations, and clinical applicability.

Main Results:

  • Diverse methodologies exist for beta-cell function assessment, each with pros and cons.
  • Advanced modeling and AI offer novel approaches to evaluating secretory capacity.
  • Effective beta-cell assessment can improve diagnostic accuracy and personalize therapy.

Conclusions:

  • Optimizing T2DM management requires a structured framework for beta-cell assessment.
  • Evaluating beta-cell function is critical for predicting and achieving diabetes remission.
  • Integrating technical insights with clinical practice enhances patient outcomes in T2DM.